Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Thachil, Thanuja
Lamichhane, Shree Ram
Gee, Harriet
Milic, Natalie
De Ieso, Paolo
Moss, Simon Andrew
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-21
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
MicroRNAs (miRNAs) have been found to play an important role in the development and outcomes for multiple human cancers.
Their role as a prognostic biomarker in non-small-cell lung cancer (NSCLC) remains unclear.
This meta-analysis aims to clarify the role of various miRNAs in the survival of NSCLC patients.
Materials and Methods.
All studies were identified through medical database search engines.
A meta-analysis was conducted to assess the correlation between miRNAs expressions and overall survival among those NSCLC studies.
Relevant data were extracted from each eligible study regarding baseline characteristics and key statistics such as hazard ratio (HR), 95% confidence interval (CI), and P value, which were utilized to calculate a pooled effect size.
Result.
Thirty-two studies were included in the meta-analysis.
Using a random effect model, the combined HR and 95% CI for overall survival (OS) was calculated as 1.59 (1.39–1.82), predicting a poor overall survival.
Five miRNAs (miR-21, miR-155, miR-let-7, miR-148a, and miR-148b) were found to be of significance for predicting OS in at least two studies, hence, selected for subgroup analysis.
Subgroup analysis disclosed that elevated levels of miR-21 and miR-155 in both cancer tissue and blood samples were associated with worse OS.
Compared to American studies (I-squared: <0.001% and P value: 0.94), Asian and European studies exhibited greater heterogeneity in miRNA expression and relationship to OS (I-squared, P values were approximately 78.85%, <0.001 and 61.28%, 0.006, respectively).
These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC.
Conclusion.
miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS.
These miRNAs show potential as useful prognostic biomarkers in the diagnosis, treatment, and follow-up of NSCLC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lamichhane, Shree Ram& Thachil, Thanuja& De Ieso, Paolo& Gee, Harriet& Moss, Simon Andrew& Milic, Natalie. 2018. Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1153690
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lamichhane, Shree Ram…[et al.]. Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Disease Markers No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1153690
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lamichhane, Shree Ram& Thachil, Thanuja& De Ieso, Paolo& Gee, Harriet& Moss, Simon Andrew& Milic, Natalie. Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1153690
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153690
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر