Ethanol Extract of Mylabris phalerata Inhibits M2 Polarization Induced by Recombinant IL-4 and IL-13 in Murine Macrophages
المؤلفون المشاركون
Ma, Jin Yeul
Chung, Hwan-Suck
Lee, Bong-Seon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Mylabris phalerata (MP) is an insect used in oriental herbal treatments for tumor, tinea infections, and stroke.
Recent studies have shown that tumor-associated macrophages (TAM) have detrimental roles such as tumor progression, angiogenesis, and metastasis.
Although TAM has phenotypes and characteristics in common with M2-polarized macrophages, M1 macrophages have tumor suppression and immune stimulation effects.
Medicines polarizing macrophages to M1 have been suggested to have anticancer effects via the modulation of the tumor microenvironment.
In this line, we screened oriental medicines to find M1 polarizing medicines in M2-polarized macrophages.
Among approximately 400 types of oriental medicine, the ethanol extract of M.
phalerata (EMP) was the most proficient in increasing TNF-α secretion in M2-polarized macrophages and TAM.
Although EMP enhanced the levels of an M1 cytokine (TNF-α) and a marker (CD86), it significantly reduced the levels of an M2 marker (arginase-1) in M2-polarized macrophages.
In addition, EMP-treated macrophages increased the levels of M1 markers (Inos and Tnf-α) and reduced those of the enhanced M2 markers (Fizz-1, Ym-1, and arginase-1).
EMP-treated macrophages significantly reduced Lewis lung carcinoma cell migration in a transwell migration assay and inhibited EL4-luc2 lymphoma proliferation.
In our mechanism study, EMP was found to inhibit STAT3 phosphorylation in M2-polarized macrophages.
These results suggest that EMP is effective in treating TAM-mediated tumor progression and metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chung, Hwan-Suck& Lee, Bong-Seon& Ma, Jin Yeul. 2017. Ethanol Extract of Mylabris phalerata Inhibits M2 Polarization Induced by Recombinant IL-4 and IL-13 in Murine Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153695
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chung, Hwan-Suck…[et al.]. Ethanol Extract of Mylabris phalerata Inhibits M2 Polarization Induced by Recombinant IL-4 and IL-13 in Murine Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1153695
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chung, Hwan-Suck& Lee, Bong-Seon& Ma, Jin Yeul. Ethanol Extract of Mylabris phalerata Inhibits M2 Polarization Induced by Recombinant IL-4 and IL-13 in Murine Macrophages. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1153695
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153695
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر