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Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress
المؤلفون المشاركون
Imam, Mustapha Umar
Hou, Zhiping
Peiyuan, He
Chengjun, Song
Chunqing, Wang
Bingqing, Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the hepatoprotective effects of resveratrol in alcoholic liver disease (ALD).
Alcohol was administered to healthy female rats starting from 6% (v/v) and gradually increased to 20% (v/v) by the fifth week.
After 16 weeks of intervention, liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) were analyzed using a chemistry analyzer, while hepatic antioxidant enzymes, oxidative stress markers, and caspase 3 activity were assessed using ELISA kits.
Furthermore, hepatic CYP2E1 protein levels and mRNA levels of antioxidant and inflammation-related genes were determined using western blotting and RT-PCR, respectively.
The results showed that resveratrol significantly attenuated alcohol-induced elevation of liver enzymes and improved hepatic antioxidant enzymes.
Resveratrol also attenuated alcohol-induced CYP2E1 increase, oxidative stress, and apoptosis (caspase 3 activity).
Moreover, genes associated with oxidative stress and inflammation were regulated by resveratrol supplementation.
Taken together, the results suggested that resveratrol alleviated ALD through regulation of oxidative stress, apoptosis, and inflammation, which was mediated at the transcriptional level.
The data suggests that resveratrol is a promising natural therapeutic agent against chronic ALD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peiyuan, He& Hou, Zhiping& Chengjun, Song& Chunqing, Wang& Bingqing, Li& Imam, Mustapha Umar. 2017. Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peiyuan, He…[et al.]. Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peiyuan, He& Hou, Zhiping& Chengjun, Song& Chunqing, Wang& Bingqing, Li& Imam, Mustapha Umar. Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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