Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction
المؤلفون المشاركون
Zhang, Yujing
Zhong, Peng
Xu, Yingze
Wang, Baokui
Zhu, Tao
Zhang, Wendi
Wang, Haihua
Wei, Zixiu
Huang, Jian
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Acute myocardial infarction (AMI) is the most serious type of coronary atherosclerotic heart disease (CAD).
The pathological changes are characterized by atherosclerosis.
Oxidative stress plays an important role in atherosclerosis.
Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor and regulator of thioredoxin, could bind thioredoxin to regulate its expression and antioxidant activity negatively.
The NCBI data show that there are two isoforms in TXNIP gene, namely, TXNIP1 and TXNIP2.
Our previous studies have shown that TXNIP expression levels in patients with unstable angina pectoris (UAP) were increased compared with controls (CTR).
However, no upregulation of TXNIP was detected in AMI patients.
Methods.
The leucocytes were isolated from peripheral venous blood, and total RNA of the leucocytes was extracted.
Then, real-time quantitative PCR was performed.
Results.
mRNA levels of TXNIP2 in AMI were significantly increased compared with CTR (P<0.05).
However, the expression of TXNIP1 was downregulated in AMI, but the difference was not statistically significant (P>0.05).
Logistic regression analysis showed that TXNIP2 mRNA levels were significantly associated with AMI (OR = 2.207, P<0.05).
Conclusions.
The expression of TXNIP2, not TXNIP1, is upregulated in leukocytes of AMI patients, indicating that only TXNIP2 in circulating leucocytes may be involved in the pathogenesis of AMI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yujing& Zhong, Peng& Xu, Yingze& Wang, Baokui& Zhu, Tao& Zhang, Wendi…[et al.]. 2018. Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction. Disease Markers،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153737
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yujing…[et al.]. Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction. Disease Markers No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1153737
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yujing& Zhong, Peng& Xu, Yingze& Wang, Baokui& Zhu, Tao& Zhang, Wendi…[et al.]. Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1153737
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153737
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر