Comparative Clinical Analysis of Gastroenteropancreatic Neuroendocrine Carcinomas with Liver Metastasis and Primary Hepatic Neuroendocrine Carcinomas
المؤلفون المشاركون
Yang, Sheng-Li
Xiong, Zhi-Fan
He, Xiaoxiao
Qiu, Meng-jun
Chen, Yao-bing
Bi, Ning-rui
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
The objective of this study was to analyze the clinical features and prognosis of gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) with liver metastasis and primary hepatic neuroendocrine carcinomas (PHNECs), as these rare hepatic neuroendocrine carcinomas have not been exhaustively studied.
Methods.
The clinical data of 47 patients with hepatic NECs were retrospectively reviewed and categorized to analyze features and prognosis.
Results.
The 47 studied cases comprised 13 cases of primary hepatic NECs (primary group) and 34 cases of metastatic hepatic NECs (metastatic group).
Male patients were slightly dominant in both groups, while no age predilection was present.
PHNECs were mostly single nodules located in the right lobe of the liver.
Metastatic hepatic NECs originated mostly from the pancreas and stomach without distinction of the lobes of the liver.
Univariate analysis showed that the treatment protocol (radical operation or others) was correlated with the overall survival (OS; p<0.05) in the primary group, while treatment protocol and cytokeratin 7 (CK7) were associated with OS (p<0.05) in the metastatic group.
Cox proportional hazard regression showed that radical operation was an independent prognostic factor (p<0.05) for OS in the metastatic group.
Conclusions.
No significant differences in the clinicopathological features between PHNECs and metastatic hepatic GEP NECs were found, but radical operation was significantly correlated with OS for both carcinomas.
Radical operation is the first choice for patients who are eligible for operation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiu, Meng-jun& Chen, Yao-bing& Bi, Ning-rui& Yang, Sheng-Li& He, Xiaoxiao& Xiong, Zhi-Fan. 2018. Comparative Clinical Analysis of Gastroenteropancreatic Neuroendocrine Carcinomas with Liver Metastasis and Primary Hepatic Neuroendocrine Carcinomas. Disease Markers،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153746
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiu, Meng-jun…[et al.]. Comparative Clinical Analysis of Gastroenteropancreatic Neuroendocrine Carcinomas with Liver Metastasis and Primary Hepatic Neuroendocrine Carcinomas. Disease Markers No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1153746
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiu, Meng-jun& Chen, Yao-bing& Bi, Ning-rui& Yang, Sheng-Li& He, Xiaoxiao& Xiong, Zhi-Fan. Comparative Clinical Analysis of Gastroenteropancreatic Neuroendocrine Carcinomas with Liver Metastasis and Primary Hepatic Neuroendocrine Carcinomas. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153746
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153746
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر