Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders
المؤلفون المشاركون
Duan, Liang
Chen, Shu
Zhang, Fei-Fei
Li, Dan-Dan
Zhang, Juan
Chen, Wei-Xian
Chen, Hong
Wang, Bo
Hu, Qin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Substantial advance supports that CMTM2 serve as an important performer in physiological and pathological processes.
However, very little is clear about the relationship between CMTM2 and HBV-related disorders.
Here, for the first time, we explore that whether or not serum CMTM2 is involved in HBV-related diseases.
We found that CMTM2 values were significantly lower in patients compared to healthy control (p <0.001), using ELISA assay.
Furthermore, serum CMTM2 levels were negatively correlated with HBV DNA levels in CHB patients but not correlated with the serum levels of ALT and AST.
Serum CMTM2 concentrations were not correlated with the serum levels of ALT, AST and HBV DNA load in HBLC and HCC patients.
In addition, analysis of the ROC curve indicated that CMTM2 levels were significantly associated with the diagnostic value of HBV-related disorders.
Finally, downregulation of CMTM2 was observed in HBV-infected cell model.
CMTM2 degradation could be attributed to HBx-activated Lys48 (K48)-linked polyubiquitination, which was abolished by treatment with the proteasome inhibitor MG132.
HBV infection suppresses CMTM2 expression by activating ubiquitin-proteasome system.
Serum CMTM2 levels can be adopted as an effective indicator of the pathogenesis of HBV-related disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Shu& Hu, Qin& Chen, Hong& Zhang, Fei-Fei& Duan, Liang& Wang, Bo…[et al.]. 2020. Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153769
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Shu…[et al.]. Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1153769
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Shu& Hu, Qin& Chen, Hong& Zhang, Fei-Fei& Duan, Liang& Wang, Bo…[et al.]. Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153769
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153769
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر