Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
المؤلفون المشاركون
Koo, Ja Seung
Choi, Junjeong
Kim, Eun-Sol
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer.
Methods.
Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers.
mRNA levels of these markers in publicly available data from the Cancer Genome Atlas project and Kaplan-Meier plotters were analyzed.
Results.
Expression of G6PDH and 6PGL was higher in HER-2 type (p<0.001 and p=0.009, resp.) and lower in luminal A type.
6PGDH expression was detected only in TNBC subtype (p<0.001).
G6PDH positivity was associated with ER negativity (p=0.001), PR negativity (p=0.001), and HER-2 positivity (p<0.001), whereas 6PGL positivity was associated with higher T stage (p=0.004).
The 562 expression profile from the TCGA database revealed increased expression of G6PDH and 6PG in the tumor compared with normal adjacent breast tissue.
The expression of G6PDH was highest in HER-2 type.
HER-2 and basal-like subtypes showed higher expression of 6PGDH than luminal types.
Conclusion.
PPP-related proteins are differentially expressed in breast cancer according to molecular subtype, and higher expression of G6PDH and 6PGL was noted in HER-2 subtype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Junjeong& Kim, Eun-Sol& Koo, Ja Seung. 2018. Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer. Disease Markers،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Junjeong…[et al.]. Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer. Disease Markers No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Junjeong& Kim, Eun-Sol& Koo, Ja Seung. Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر