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Prognostic Role of Serum Amino Acids in Head and Neck Cancer
المؤلفون المشاركون
Persichilli, Silvia
Primiano, Aniello
Arzani, Dario
Cadoni, Gabriella
Giraldi, Luca
Chiarla, Carlo
Settimi, Stefano
Galli, Jacopo
Paludetti, Gaetano
Almadori, Giovanni
Gervasoni, Jacopo
Giovannini, Ivo
Boccia, Stefania
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient.
The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients.
Methods.
Two hundred and two primary HNC patients were included in the study.
Thirty-one AAs and derivatives were measured in serum through an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS).
The association between AA concentrations and the stage (advanced versus early) of HNC was estimated using a multivariable logistic regression model.
A multivariable Cox regression model was used to evaluate the prognostic significance of each AA.
Results.
At the multivariable logistic regression analysis, increased levels of alpha-aminobutyric acid, aminoadipic acid, histidine, proline, and tryptophan were associated with a reduced risk of advanced stage HNC, while high levels of beta-alanine, beta-aminobutyric acid, ethanolamine, glycine, isoleucine, 4-hydroxyproline, and phenylalanine were associated with an increased risk of advanced stage HNC.
Furthermore, at multivariate analysis, increased levels of alpha-aminobutyric acid were associated with increased overall survival (OS), while high levels of arginine, ethanolamine, glycine, histidine, isoleucine, 4-hydroxyproline, leucine, lysine, 3-methylhistidine, phenylalanine, and serine were associated with decreased OS.
Conclusions.
Our study suggests that AA levels are associated with the stage of disease and prognosis in patients with HNC.
More study is necessary to evaluate if serum AA levels may be considered a hallmark of HNC and prove to be clinically useful markers of disease status and prognosis in HNC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cadoni, Gabriella& Giraldi, Luca& Chiarla, Carlo& Gervasoni, Jacopo& Persichilli, Silvia& Primiano, Aniello…[et al.]. 2020. Prognostic Role of Serum Amino Acids in Head and Neck Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cadoni, Gabriella…[et al.]. Prognostic Role of Serum Amino Acids in Head and Neck Cancer. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cadoni, Gabriella& Giraldi, Luca& Chiarla, Carlo& Gervasoni, Jacopo& Persichilli, Silvia& Primiano, Aniello…[et al.]. Prognostic Role of Serum Amino Acids in Head and Neck Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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