Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes
المؤلفون المشاركون
Liu, Bin
Zhang, Wenjing
Li, Yi
Li, Rui
Wang, Yaya
Zhu, Mengwen
Wang, Bowen
Li, Yanling
Li, Dongyun
Xie, Ping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The present study was designed to elucidate the key parameters associated with X-ray radiation induced oxidative stress and the effects of STS on X-ray-induced toxicity in H9c2 cardiomyocytes.
Cytotoxicity of STS and radiation was assessed by MTT.
Antioxidant activity was evaluated by SOD and MDA.
Apoptosis was measured by the flow cytometry, Hoechst 33258, clonogenic survival assay, and western blot.
It was found that the cell viability of H9c2 cells exposed to X-ray radiation was significantly decreased in a dose-dependent manner and was associated with cell cycle arrest at the G0/G1 phase as well as apoptosis.
STS treatment significantly reversed the morphological changes, attenuated radiation-induced apoptosis, and improved the antioxidant activity in the H9c2 cells.
STS significantly increased the Bcl-2 and Bcl-2/Bax levels and decreased the Bax and caspase-3 levels, compared with the cells treated with radiation alone.
STS treatment also resulted in a significant increase in p38-MAPK activation.
STS could protect the cells from X-ray-induced cell cycle arrest, oxidative stress, and apoptosis.
Therefore, we suggest the STS could be useful for the treatment of radiation-induced cardiovascular injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wenjing& Li, Yi& Li, Rui& Wang, Yaya& Zhu, Mengwen& Wang, Bowen…[et al.]. 2017. Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wenjing…[et al.]. Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1153779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wenjing& Li, Yi& Li, Rui& Wang, Yaya& Zhu, Mengwen& Wang, Bowen…[et al.]. Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1153779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر