Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer
المؤلفون المشاركون
Chen, Zhong-qing
Huang, Ling-sha
Zhu, Bo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported.
Methods.
TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), and 103 cases of benign chest disease (BCD) were analyzed before treatment.
Results.
By Kendall’s tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC (r=0.235, p<0.05; r=0.298, p<0.05; r=0.254, p<0.05; r=0.063, p<0.05; r=0.080, p<0.05; r=0.268, p<0.05; and r=0.080, p<0.05).
CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with N stage of LAC (r=0.356, p<0.05; r=0.415, p<0.05; r=0.340, p<0.05; r=0.117, p<0.05; r=0.175, p<0.05; and r=0.351, p<0.05).
CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with M stage of LAC (r=0.365, p<0.05; r=0.353, p<0.05; r=0.293, p<0.05; r=0.135, p<0.05; r=0.169, p<0.05; and r=0.312, p<0.05).
CA125, CYFRA21-1, and SCC-Ag were correlated with T stage of LSCC (r=0.202, p<0.05; r=0.233, p<0.05; and r=0.099, p<0.05).
CA125 and CYFRA21-1 were correlated with N stage of LSCC (r=0.178, p<0.05 and r=0.284, p<0.05).
CA125, CA15-3, and CYFRA21-1 were correlated with M stage of LSCC (r=0.214, p<0.05; r=0.152, p<0.05; and r=0.213, p<0.05).
Combining hazard ratio, AUC, sensitivity, specificity, NPV, and PPV, it was concluded that CEA and CYFRA21-1were the most related TM of LAC.
SCC-Ag and CYFRA21-1 were the most related TM of LSCC.
Conclusions.
CEA combined with CYFRA21-1 contributed to auxiliary diagnosis of LAC.
CYFRA21-1 combined with SCC-Ag contributed to auxiliary diagnosis of LSCC.
CEA, CA125, CA15-3, CA19-9, CA72-4, and CYFRA21-1 were correlated with primary tissue and metastasis of LAC.
CA125 and CYFRA21-1 were correlated with primary tissue and metastasis of LSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Zhong-qing& Huang, Ling-sha& Zhu, Bo. 2018. Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer. Disease Markers،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Zhong-qing…[et al.]. Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer. Disease Markers No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1153804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Zhong-qing& Huang, Ling-sha& Zhu, Bo. Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1153804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر