MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer
المؤلفون المشاركون
Ye, Zhi-qiang
Zou, Chang-lin
Chen, Han-bin
Jiang, Ming-jie
Mei, Zhu
Gu, Dian-na
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
MicroRNAs play critical roles in tumor progression.
Our recent study has indicated that microRNA-7 (miR-7) impairs autophagy-derived pools of glucose to suppress the glycolysis in pancreatic cancer progression.
However, the roles of miR-7 in clinical significance and chemoresistance of pancreatic cancer remain unexplored.
The aim of this study was to assess the expression of miR-7 in patients with pancreatic cancer and to evaluate the possibility of its usage as a prognostic molecular biomarker.
MicroRNA array-based quantification analysis of 372 miRNAs was compared in serum between pancreatic cancer and healthy individuals, gemcitabine-sensitive and gemcitabine-resistance patients.
We identified miR-7 showed the potential predictive power for gemcitabine-sensitive patients with pancreatic cancer.
Then, the results were validated in pancreatic tissue microarray and The Cancer Genome Atlas (TCGA) dataset, demonstrating that lower miR-7 expression was correlated with more advanced tumor stages and worse prognosis in pancreatic cancer.
The Cox proportional-hazards model analysis identified miR-7 to be an independent variable for prediction of the survival.
Furthermore, the mechanistic exploration suggested the clinical significance of miR-7 involved its interference effect on autophagy and glycolysis in pancreatic cancer using pancreatic cancer tissue microarrays and TCGA data.
Therefore, the results of the present study provide evidences that low microRNA-7 expression may contribute to tumor progression and poor prognosis in pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Zhi-qiang& Zou, Chang-lin& Chen, Han-bin& Jiang, Ming-jie& Mei, Zhu& Gu, Dian-na. 2020. MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Zhi-qiang…[et al.]. MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1153808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Zhi-qiang& Zou, Chang-lin& Chen, Han-bin& Jiang, Ming-jie& Mei, Zhu& Gu, Dian-na. MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر