Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer
المؤلفون المشاركون
Lu, Bin
Shi, Liyun
Zhang, Cong
Xu, Shuo
Xiang, Chunjie
Yang, Dongqing
Tong, Ruimin
Teng, Yuhao
Zhang, Junfeng
Dong, Wei
Wu, Juan
Wang, Ruiping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-16
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Although intestinal microbial dysbiosis was confirmed to be associated with many chronic diseases and health status through complicated interaction with the host, the effect on gastric cancer was less studied.
In this study, we sequenced the 16S rRNA and 18S rRNA genes of fecal bacteria and fungi, respectively, in 134 gastric cancer patients and 58 healthy controls matched by age and gender.
Propensity score matching (PSM) was adopted for adjusting diet habits and lifestyle, and 44 patients and 44 healthy controls (matching population) were enrolled.
Serum antibody to H.
pylori and metabolites of the matching population were detected.
The positive rates of antibody to H.
pylori between the patients and the control group did not reach the statistical difference.
LEfSe analysis indicated that bacteria were more stable than fungi when adjusting diet and lifestyle.
Veillonella, Megasphaera, and Prevotella 7 genus and Streptococcus salivarius subsp.
Salivarius, Bifidobacterium dentium, and Lactobacillus salivarius species in bacteria were related to the risk of gastric cancer and showed a good diagnostic value in distinguishing the patients from healthy controls.
Streptococcus mitis showed a risk effect for gastric cancer; however, the effect turned into be protective after PSM.
Serum L-alanine, L-threonine, and methionol were positively associated with Veillonella and Streptococcus and several fungi genus.
Overall, our findings indicated that fecal microbiome constitution alteration may be associated with gastric cancer through influencing the amino acid metabolism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Juan& Zhang, Cong& Xu, Shuo& Xiang, Chunjie& Wang, Ruiping& Yang, Dongqing…[et al.]. 2020. Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1153822
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Juan…[et al.]. Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer. Disease Markers No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1153822
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Juan& Zhang, Cong& Xu, Shuo& Xiang, Chunjie& Wang, Ruiping& Yang, Dongqing…[et al.]. Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1153822
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153822
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر