Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma
المؤلفون المشاركون
Lu, Liang-He
Wei-Wei, Liang-He
Kan, Anna
Jie-Mei, Anna
Ling, Yi-Hong
Li, Shao-Hua
Guo, Rong-Ping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Gamma-glutamyltransferase (GGT) is involved in tumor development and progression, but its prognostic value in α-fetoprotein- (AFP-) negative (AFP<25 ng/mL) hepatocellular carcinoma (HCC) patients remains unknown.
Methods.
A large cohort of 678 patients with AFP-negative HCC following curative resection who had complete data were enrolled in this study.
The optimal cutoff value for the preoperative level of GGT was determined by the X-tile program.
Independent prognostic factors for overall survival (OS) and disease-free survival (DFS) were also identified.
Results.
The optimal cutoff values for the preoperative levels of GGT were 37.2 U/L and 102.8 U/L, which were used to divide all patients into three subgroups (group 1, GGT<37.2 U/L (n=211, 31.1%); group 2, GGT≥37.2 and <102.8 U/L (n=320, 47.2%); group 3, GGT≥102.8 U/L (n=147, 21.7%)), with distinct OS times (58.5 vs.
53.5 vs.
44.4 months, P<0.001) and DFS times (47.9 vs.
40.3 vs.
30.1 months, P<0.001).
Elevated preoperative GGT levels were associated with an unfavorable tumor burden (larger tumor size, multiple tumors, and microvascular invasion) and were selected as independent predictors of a worse OS (group 2 vs.
group 1, HR: 1.73 (1.13-2.65), P=0.011; group 3 vs.
group 1, HR: 3.28 (2.10-5.13), P<0.001) and DFS (group 2 vs.
group 1, HR: 1.52 (1.13-2.05), P=0.006; group 3 vs.
group 1, HR: 2.11 (1.49-2.98), P<0.001) in multivariable analysis.
Conclusions.
Elevated preoperative GGT levels are associated with an unfavorable tumor burden and serve as an independent prognostic marker for worse outcomes in AFP-negative HCC patients following resection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Liang-He& Wei-Wei, Liang-He& Kan, Anna& Jie-Mei, Anna& Ling, Yi-Hong& Li, Shao-Hua…[et al.]. 2020. Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Liang-He…[et al.]. Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1153838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Liang-He& Wei-Wei, Liang-He& Kan, Anna& Jie-Mei, Anna& Ling, Yi-Hong& Li, Shao-Hua…[et al.]. Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر