The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA
المؤلفون المشاركون
Wang, Jirong
Shen, Chengquan
Yang, Xiaokun
Niu, Haitao
Wang, Yonghua
Liu, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
PTPN6 (protein tyrosine phosphatase nonreceptor type 6), a tyrosine phosphatase, is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
Previous studies have demonstrated that PTPN6 expression is relatively elevated in several malignancies.
However, the role of PTPN6 in bladder cancer (BC) remains unclear.
The purpose of this study was to explore the prognostic value of PTPN6 in BC.
RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 in BC.
The relationship between clinical pathologic features and PTPN6 were analyzed with the Wilcoxon signed-rank test.
The prognostic and predictive value of PTPN6 was evaluated by survival analysis and nomogram.
Gene Set Enrichment Analysis (GSEA) was conducted to explore the potential molecular mechanisms of PTPN6 in BC.
Finally, Tumor Immune Estimation Resource (TIMER) was applied to investigate the relationship between PTPN6 and immune cell infiltration in the tumor microenvironment.
Results indicated that PTPN6 was overexpressed in BC tissues compared with normal bladder tissues and was significantly correlated with grade, stage, T, and N.
Survival analysis showed that low expression of PTPN6 was significantly related to the poor overall survival (OS) in BC patients.
Coexpression analysis showed that PTPN6 and TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) have a close correlation in BC.
GSEA showed that multiple cancer-associated signaling pathways are differentially enriched in the PTPN6 high expression phenotype.
Moreover, the expression level of PTPN6 was positively associated with the infiltration of B cells, CD4+T cells, dendritic cells, and neutrophils and negatively associated with CD8+ T cells and macrophages in BC.
In conclusion, we identified that PTPN6 may be a novel prognostic biomarker in BC based on the TCGA database.
Further clinical trials are needed to confirm our observations and mechanisms underlying the prognostic value of PTPN6 in BC also deserve further experimental exploration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Chengquan& Liu, Jing& Wang, Jirong& Yang, Xiaokun& Niu, Haitao& Wang, Yonghua. 2020. The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Chengquan…[et al.]. The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Chengquan& Liu, Jing& Wang, Jirong& Yang, Xiaokun& Niu, Haitao& Wang, Yonghua. The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر