Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital
المؤلفون المشاركون
Chatproedprai, Susheera
Wutticharoenwong, Vanvara
Tempark, Therdpong
Wananukul, Siriwan
المصدر
Dermatology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children.
Methods.
A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand.
Results.
36 patients (M : F, 16 : 20) with the mean age of 9.2±4.0 years were identified.
There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN.
Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%).
Cutaneous morphology at presentation was morbilliform rash (83.3%), blister (38.9%), targetoid lesions (25.0%), and purpuric macules (2.8%).
Oral mucosa (97.2%) and eye (83.3%) were the 2 most common mucosal involvements.
Majority of the cases (77.8%) were treated with systemic corticosteroids, intravenous immunoglobulin, or both.
Treatment outcomes between those who received systemic therapy and those who received only supportive care were comparable.
Skin and eye were the principal sites of short-term and long-term complications.
Conclusions.
SJS/TEN are not common but are serious diseases which lead to significant morbidities in children.
Early withdrawal of suspicious causes and meticulous supportive care are very important.
This study found that the systemic therapy was not superior to supportive care because the treatment outcomes for both groups were comparable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chatproedprai, Susheera& Wutticharoenwong, Vanvara& Tempark, Therdpong& Wananukul, Siriwan. 2018. Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chatproedprai, Susheera…[et al.]. Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital. Dermatology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1153848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chatproedprai, Susheera& Wutticharoenwong, Vanvara& Tempark, Therdpong& Wananukul, Siriwan. Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1153848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر