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Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats
المؤلفون المشاركون
Li, Bo
Pang, Min-Xia
Chen, Su-Hong
Lv, Gui-Yuan
Shi, Jun-ping
Zhuang, Zhen-Jie
Shan, Chao-Wen
Wang, Han
Luo, Yan
Liu, Yin-lan
Song, Yu
Wang, Nan-Nan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study was to explore the potential beneficial effects of linarin enriched Flos Chrysanthemi extract (Lin-extract) on nonalcoholic steatohepatitis (NASH) induced by high-fat high-cholesterol (HFHC) diet in rats.
SD rats received normal diet, HFHC diet, or HFHC diet plus different doses of Lin-extract.
The liver content of triglyceride and total cholesterol markedly increased in HFHC diet-fed model rats while middle and high dose of Lin-extract lowered liver cholesterol significantly.
The expression of stearoyl-CoA desaturase (SCD1) was upregulated by HFHC diet and further elevated by high dose Lin-extract.
High dose of Lin-extract also markedly lowered the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and inhibited the activation of c-Jun N-terminal kinase (JNK) induced by HFHC in livers.
The HFHC-increased mRNA levels of hepatic inflammation cytokines, including monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and chemokine (C-X-C motif) ligand 1 (CXCL1), were suppressed by Lin-extract dose-dependently.
Furthermore, pathology evaluation showed that high dose Lin-extract greatly improved lobular inflammation.
Our results suggest that Lin-extract could attenuate liver injury and inflammation induced by HFHC diet in rats.
Its modulatory effect on lipid metabolism may partially contribute to this protective effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhuang, Zhen-Jie& Shan, Chao-Wen& Li, Bo& Pang, Min-Xia& Wang, Han& Luo, Yan…[et al.]. 2017. Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhuang, Zhen-Jie…[et al.]. Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhuang, Zhen-Jie& Shan, Chao-Wen& Li, Bo& Pang, Min-Xia& Wang, Han& Luo, Yan…[et al.]. Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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