Clinicopathological Significance of Neuropilin 1 Expression in Gastric Cancer: A Meta-Analysis
المؤلفون المشاركون
Huang, Limin
Bai, Banjun
Xu, Zhong
Li, Yan
Cao, Hui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Neuropilin 1 (NRP1) is involved in tumorigenesis, development, invasion, and metastasis by promoting angiogenesis of tumors.
The study is aimed at evaluating the correlation between the expression of NRP1 protein and clinicopathological features of gastric cancer by meta-analysis.
Methods.
The published studies were searched in databases including CNKI, Wanfang, Chongqing VIP, Web of Science, and PubMed online.
Clinical case studies were included to compare the correlation between NRP1 protein expression and clinicopathological characteristics of gastric cancer.
The quality of the included literatures was evaluated by NOS scale.
Meta-analysis was performed by Stata software to calculate the odds ratio (OR) and 95% confidence interval (CI).
Results.
A total of 12 studies were included in this analysis, involving 1,225 patients with gastric cancer.
The analysis indicated that the expression of NRP1 protein in gastric cancer tissues was lower in the group of early stage versus advanced stage (OR=0.128, 95%CI=0.059−0.277, P≤0.001), tumor size less than 5 cm versus more than 5 cm (OR=0.443, 95%CI=0.310−0.632, P≤0.001), TNM stage I-II group versus stage III-IV patients (OR=0.736, 95%CI=0.589−0.919, P=0.007), well to medium differentiation group versus poor differentiation group (OR=0.735, 95%CI=0.632−0.854, P≤0.001), and nonlymph node metastasis group versus lymph node metastasis group (OR=0.667, 95%CI=0.522−0.854, P≤0.001).
The expression of NRP1 protein in gastric cancer was not related to gender, age, and Laurèn’s classification.
Conclusion.
The expression of NRP1 protein in gastric cancer is closely correlated to clinical stage, tumor size, TNM stage, differentiation, and lymph node metastasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Hui& Li, Yan& Huang, Limin& Bai, Banjun& Xu, Zhong. 2020. Clinicopathological Significance of Neuropilin 1 Expression in Gastric Cancer: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153856
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Hui…[et al.]. Clinicopathological Significance of Neuropilin 1 Expression in Gastric Cancer: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153856
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Hui& Li, Yan& Huang, Limin& Bai, Banjun& Xu, Zhong. Clinicopathological Significance of Neuropilin 1 Expression in Gastric Cancer: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153856
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153856
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر