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Association of WISP1CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women
المؤلفون المشاركون
Ma, Yanan
Wang, Yinuo
Wang, Ningning
Gao, Ming
Hu, Jiajin
Wei, Xiaotong
Wen, Deliang
Liu, Lei
Liu, Yang
Yang, Liu
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone.
Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters.
Methods.
A total of 313 participants were screened from a multicenter prospective prebirth cohort: Born in Shenyang Cohort Study (BISCS).
Subjects were examined with a 2×2 factorial design for body mass index BMI≥24 and GDM.
Between 24 and 28 weeks of pregnancy, follow-up individuals underwent an OGTT and blood sampling for cardiometabolic characterization.
Results.
We observed that the WISP1 levels were elevated in prepregnancy overweight/obesity patients with GDM, compared with nonoverweight subjects with normal blood glucose (3.45±0.89 vs.
2.91±0.75 ng/mL).
Multilogistic regression analyses after adjustments for potential confounding factors revealed that WISP1 was a strong and independent risk factor for prepregnancy overweight/obesity with GDM (all ORs>1).
In addition, the results of the ROC analysis indicated that WISP1 exhibited the capability to identify individuals with prepregnancy overweight/obesity and GDM (all AUC>0.5).
Finally, univariate and multivariate linear regression showed that WISP1 level was positively and independently correlated with fasting blood glucose, systolic blood pressure, and aspartate aminotransferase and was negatively correlated with HDL-C and complement C1q.
Conclusions.
WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Lei& Hu, Jiajin& Yang, Liu& Wang, Ningning& Liu, Yang& Wei, Xiaotong…[et al.]. 2020. Association of WISP1CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Lei…[et al.]. Association of WISP1CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1153869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Lei& Hu, Jiajin& Yang, Liu& Wang, Ningning& Liu, Yang& Wei, Xiaotong…[et al.]. Association of WISP1CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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