A Comprehensive Exploration of the lncRNA CCAT2: A Pan-Cancer Analysis Based on 33 Cancer Types and 13285 Cases
المؤلفون المشاركون
Huang, Bowen
Yu, Min
Guan, Renguo
Liu, Dong
Hou, Baohua
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Whether the lncRNA CCAT2 expression level affects the clinical progression and outcome of cancer patients has not yet been fully elucidated.
There is still an inconsistent view regarding the correlation between CCAT2 expression and clinicopathological factors, including survival data.
Besides, the regulation mechanism of CCAT2 in human cancer is still unclear.
Our study analyzed a large number of publication data and TCGA databases to identify the association of CCAT2 expression with clinicopathological factors and to explore the regulatory mechanisms in human cancers.
We designed a comprehensive study to determine the expression of CCAT2 in human cancer by designing a meta-analysis of 20 selected studies and the TCGA database, using StataSE 12.0 to explore the relationship between CCAT2 expression and both the prognosis and clinicopathological features of 33 cancer types and 13285 tumor patients.
Moreover, we performed GO and KEGG pathway enrichment analyses on potential target genes of CCAT2 collected from GEPIA and LncRNA2Target V2.0.
The level of CCAT2 expression in tumor tissues is higher than that in paired normal tissues and is significantly associated with a poor prognosis in cancer patients.
Besides, overexpression of CCAT2 was significantly associated with tumor size, clinical stage, and TNM classification.
Meanwhile, CCAT2 expression is the highest in stage II of human cancer, followed by stage III.
Finally, 111 validated target gene symbols were identified, and GO and KEGG demonstrated that the CCAT2 validation target was significantly enriched in several pathways, including microRNAs in the cancer pathway.
In summary, CCAT2 can be a potential biomarker associated with the progression and prognosis of human cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Bowen& Yu, Min& Guan, Renguo& Liu, Dong& Hou, Baohua. 2020. A Comprehensive Exploration of the lncRNA CCAT2: A Pan-Cancer Analysis Based on 33 Cancer Types and 13285 Cases. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Bowen…[et al.]. A Comprehensive Exploration of the lncRNA CCAT2: A Pan-Cancer Analysis Based on 33 Cancer Types and 13285 Cases. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1153886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Bowen& Yu, Min& Guan, Renguo& Liu, Dong& Hou, Baohua. A Comprehensive Exploration of the lncRNA CCAT2: A Pan-Cancer Analysis Based on 33 Cancer Types and 13285 Cases. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر