Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma
المؤلفون المشاركون
Liang, Jiayu
Zhu, Yuchun
Chen, Ni
Liu, Zhihong
Pei, Tianjiao
Xiao, Yingming
Zhou, Liang
Tang, Yongquan
Zhou, Chuan
Wu, Kan
Zhang, Fuxun
Zhang, Fan
Yin, Xiaoxue
Wei, Xin
Lu, Yiping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumor with a high tumor recurrence rate and poor postoperative survival.
Recent studies suggest that CD276- (B7-H3) targeted therapy represents a promising therapeutic option for solid tumors.
However, little is known about the expression status of CD276 or its association with progression and prognosis of ACC.
Methods.
Clinical data were retrospectively analyzed from patients who underwent resection of ACC at our institution (n=48).
Archived, formalin-fixed, and paraffin-embedded samples were collected for immunohistochemical analysis, and the correlation between CD276 expression and clinicopathological parameters was evaluated.
Kaplan–Meier and univariate/multivariate Cox regression methods were implemented to identify any prognostic effects.
Data from The Cancer Genome Atlas (TCGA) ACC cohort (n=77) were retrieved for quantitative validation analysis.
Results.
Positive expression of CD276 was detected on the cell membrane and in the cytoplasm of cancer cells or tumor-associated vascular cells in 91.67% (44/48) of ACCs.
Vascular expression of CD276 was associated with local aggression (higher T stage, P=0.029) and advanced ENSAT stage (P=0.02).
Specifically, patients with a higher CD276-positive cancer cell density exhibited significantly worse overall survival and recurrence-free survival in our cohort (HR=2.8, P=0.01, and HR=7.52, P<0.001, respectively) and in the validation cohort (HR=2.4, P=0.033, and HR=3.7, P<0.001, respectively).
The prognostic association remained significant in multivariate Cox regression analysis.
Further analysis indicated that CD276 participates in regulating the immune response as well as in the malignant biological behaviors of ACC.
Conclusion.
These findings highlight the immune checkpoint factor CD276 as an independent prognostic factor and a potential therapeutic target in ACC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Jiayu& Liu, Zhihong& Pei, Tianjiao& Xiao, Yingming& Zhou, Liang& Tang, Yongquan…[et al.]. 2020. Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Jiayu…[et al.]. Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1153892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Jiayu& Liu, Zhihong& Pei, Tianjiao& Xiao, Yingming& Zhou, Liang& Tang, Yongquan…[et al.]. Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر