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SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma
المؤلفون المشاركون
Li, Yongjun
Li, Baoliang
Huang, Ronghai
Zhou, Guangpeng
Wu, Zhen
Lv, Chunhua
Han, Xiaoliang
Jiang, Li
Li, Baohua
Zhang, Zhongtao
Zhang, Wei
Huang, Hao
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Early detection appears to be the most effective approach to improve the overall survival of patients with hepatocellular carcinoma (HCC).
We evaluated the potential performance of plasma SEPT9 methylation (mSEPT9) as a noninvasive biomarker for the diagnosis of patients with HCC.
Methods.
A total of 373 subjects were included, and the group consisted of 104 HCC patients, 95 with an at-risk disease, and 174 healthy controls (HC).
The methylation of mSEPT9 was determined using methylation-specific fluorescence quantitative PCR.
The diagnostic performance of plasma mSEPT9 for HCC was assessed in a single-blind manner.
Results.
The receiver operating characteristic (ROC) curve showed that plasma mSEPT9 can be used to detect and discriminate HCC with an area under the ROC curve (AUROC) of 0.961, a sensitivity of 82.7%, and specificity of 96.0% from HC.
These results showed that plasma mSEPT9 had better diagnostic performance than serum alpha fetoprotein (AFP) (AUROC 0.881, sensitivity 57.7%, and specificity 98.3%).
Similar results were noted in the detection of early-stage HCC.
When combined with serum AFP, the sensitivity increased to 91.3% and 87.7% for the detection of HCC and early-stage HCC,respectively.
Notably, the levels of plasma mSEPT9 dramatically decreased after surgery (P=0.001).
Conclusions.
Plasma SEPT9 methylation might serve as a useful and noninvasive biomarker for the diagnosis of HCC and can be used to evaluate the therapeutic efficacy of HCC treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Baoliang& Huang, Hao& Huang, Ronghai& Zhang, Wei& Zhou, Guangpeng& Wu, Zhen…[et al.]. 2020. SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Baoliang…[et al.]. SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Baoliang& Huang, Hao& Huang, Ronghai& Zhang, Wei& Zhou, Guangpeng& Wu, Zhen…[et al.]. SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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