Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients
المؤلفون المشاركون
Fattahi, Mohammad Javad
Ghahartars, Mehdi
Najafzadeh, Shiva
Abtahi, Shabnam
Ghaderi, Abbas
المصدر
Dermatology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
IL-27 has been shown to have both tumor promoting and suppressing functions.
IL-27, with its diverse influences on immune responses, has not been studied extensively in nonmelanoma skin cancers (NMSC), including Squamous and Basal Cell Carcinomas (SCC and BCC), and its roles in tumor initiation, progression, and its probable use in NMSC treatment have yet to be unveiled.
A cross-sectional analytical study was designed to investigate the serum levels of IL-27 in NMSC patients in comparison to normal individuals.
Levels of IL-27 in the sera of 60 NMSC patients along with 28 healthy controls were measured by means of quantitative enzyme-linked immunosorbent assay (ELISA).
In this study we observed that IL-27 serum levels were significantly higher in NMSC patients in comparison to healthy individuals (0.0134 versus 0.0008 ng/ml; P<0.001).
Furthermore, when subcategorized based on pathological diagnosis, both BCC and SCC patients had higher levels of IL-27 in their sera compared to controls (P=0.002 and P=0.033; respectively).
However, these levels were not different among SCC and BCC patients.
According to our results, it seems that IL-27 is involved in antitumor immune responses in NMSCs.
On the other hand, these observations might be indicative of this cytokine involvement in NMSC tumorigenesis and progression.
Therefore, administration of this cytokine for therapeutic purposes in patients with such conditions should be erred on the side of caution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghahartars, Mehdi& Najafzadeh, Shiva& Abtahi, Shabnam& Fattahi, Mohammad Javad& Ghaderi, Abbas. 2018. Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients. Dermatology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153930
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghahartars, Mehdi…[et al.]. Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients. Dermatology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153930
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghahartars, Mehdi& Najafzadeh, Shiva& Abtahi, Shabnam& Fattahi, Mohammad Javad& Ghaderi, Abbas. Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients. Dermatology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153930
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153930
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر