Identification of miRNAs as the Crosstalk in the Interaction between Neural StemProgenitor Cells and Endothelial Cells
المؤلفون المشاركون
Ziebolz, Dirk
Wang, Xin
Li, Simin
Ma, Yihong
Xu, Yuzhen
Ogbuehi, Anthony Chukwunonso
Hu, Xianda
Acharya, Aneesha
Haak, Rainer
Schmalz, Gerhard
Li, Hanluo
Gaus, Sebastian
Lethaus, Bernd
Savkovic, Vuk
Su, Zhiqiang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-29، 29ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-16
دولة النشر
مصر
عدد الصفحات
29
التخصصات الرئيسية
الملخص EN
Aim.
This study is aimed at identifying genetic and epigenetic crosstalk molecules and their target drugs involved in the interaction between neural stem/progenitor cells (NSPCs) and endothelial cells (ECs).
Materials and Methods.
Datasets pertaining to reciprocal mRNA and noncoding RNA changes induced by the interaction between NSPCs and ECs were obtained from the GEO database.
Differential expression analysis (DEA) was applied to identify NSPC-induced EC alterations by comparing the expression profiles between monoculture of ECs and ECs grown in EC/NSPC cocultures.
DEA was also utilized to identify EC-induced NSPC alterations by comparing the expression profiles between monoculture of NSPCs and NSPCs grown in EC/NSPC cocultures.
The DEGs and DEmiRNAs shared by NSPC-induced EC alterations and EC-induced NSPC alterations were then identified.
Furthermore, miRNA crosstalk analysis and functional enrichment analysis were performed, and the relationship between DEmiRNAs and small molecular drug targets/environment chemical compounds was investigated.
Results.
One dataset (GSE29759) was included and analyzed in this study.
Six genes (i.e., MMP14, TIMP3, LOXL1, CCK, SMAD6, and HSPA2), three miRNAs (i.e., miR-210, miR-230a, and miR-23b), and three pathways (i.e., Akt, ERK1/2, and BMPs) were identified as crosstalk molecules.
Six small molecular drugs (i.e., deptropine, fluphenazine, lycorine, quinostatin, resveratrol, and thiamazole) and seven environmental chemical compounds (i.e., folic acid, dexamethasone, choline, doxorubicin, thalidomide, bisphenol A, and titanium dioxide) were identified to be potential target drugs of the identified DEmiRNAs.
Conclusion.
To conclude, three miRNAs (i.e., miR-210, miR-230a, and miR-23b) were identified to be crosstalks linking the interaction between ECs and NSPCs by implicating in both angiogenesis and neurogenesis.
These crosstalk molecules might provide a basis for devising novel strategies for fabricating neurovascular models in stem cell tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xin& Li, Simin& Ma, Yihong& Xu, Yuzhen& Ogbuehi, Anthony Chukwunonso& Hu, Xianda…[et al.]. 2020. Identification of miRNAs as the Crosstalk in the Interaction between Neural StemProgenitor Cells and Endothelial Cells. Disease Markers،Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1153957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xin…[et al.]. Identification of miRNAs as the Crosstalk in the Interaction between Neural StemProgenitor Cells and Endothelial Cells. Disease Markers No. 2020 (2020), pp.1-29.
https://search.emarefa.net/detail/BIM-1153957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xin& Li, Simin& Ma, Yihong& Xu, Yuzhen& Ogbuehi, Anthony Chukwunonso& Hu, Xianda…[et al.]. Identification of miRNAs as the Crosstalk in the Interaction between Neural StemProgenitor Cells and Endothelial Cells. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1153957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر