Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis
المؤلفون المشاركون
Wang, Ya-Zhen
Dong, Xiaoyan
Gao, Wenyan
LV, Xiaoling
Wu, Qing
Yang, Zhouxin
Xing, Wenmin
Mao, Gen-Xiang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Purpose.
Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility.
The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk.
The aim of this meta-analysis was to systematically evaluate this association.
Methods.
Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria.
Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility.
Metaregression and publication bias analyses were also conducted.
All analyses were performed using the Stata 12.0 software.
Results.
Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis.
A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs.
ins: OR=0.79, 95%CI=0.72‐0.86; del/del vs.
ins/ins+del/ins: OR=0.74, 95%CI=0.59‐0.91; del/ins vs.
ins/ins: OR=0.84, 95%CI=0.67‐1.05).
For rs16901904, a decreased cancer risk was observed in three genetic models (C vs.
T: OR=0.79, 95%CI=0.70‐0.90; CC vs.
CT+TT: OR=0.49, 95%CI=0.37‐0.65; CC vs.
TT: OR=0.49, 95%CI=0.37‐0.66).
No statistical significance was found in the metaregression analysis.
For all of the included SNPs, no publication bias was found in all genotype models.
Conclusions.
The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Xiaoyan& Gao, Wenyan& LV, Xiaoling& Wang, Ya-Zhen& Wu, Qing& Yang, Zhouxin…[et al.]. 2020. Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Xiaoyan…[et al.]. Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1153972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Xiaoyan& Gao, Wenyan& LV, Xiaoling& Wang, Ya-Zhen& Wu, Qing& Yang, Zhouxin…[et al.]. Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1153972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر