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S100B Levels in Patients with Type 2 Diabetes Mellitus and Co-Occurring Depressive Symptoms
المؤلفون المشاركون
Politis, Antonis M.
Katsanou, Panagiota
Perrea, Despoina
Katsanos, Spyridon
Ntova, Vasiliki
Antrian, Virginia
Konstantopoulos, Panagiotis
Tentolouris, Nicholas
المصدر
Depression Research and Treatment
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Depression is a comorbid condition in patients with Type 2 Diabetes mellitus (T2DM).
S100B, a glia derived protein, is linked to depression and has been suggested as a biomarker for depression outcomes in several populations.
However, to date there is no data about S100B levels and depression in patients with T2DM.
Objective.
We hypothesized that S100B serum levels are increased in patients with T2DM and recently diagnosed, drug-free depressive symptoms, and could be used for the diagnosis of depression in T2DM.
Methods.
Overall 52 patients (62 ± 12 years, female 66, 7%) with no history of depression deriving from the Diabetes out-patient clinic of our University Hospital underwent a one-to-one interview with a psychiatrist and filled a self-assessment (Zung) questionnaire.
Serum S00B levels were compared between 30 (63±12 years, female 66, 7%) diabetic patients without depressive symptoms vs 22 patients (62 ±12 years, female 68, 2%) with T2DM and depressive symptoms.
Results.
There was no difference in serum levels of S100B between patients with T2DM without depressive symptoms vs diabetic patients suffering from depressive symptoms (2.1 (1.9-10.9) pg/ml vs 2.4 (1.9-14.8) pg/ml, p=0.
637+).
Moreover, linear regression analysis did not show any association between lnS100B levels and depressive symptoms (β = 0.084, 95% CI 0.470-0.871, and p=0.552), Zung self-assessment score (β = 0.048, 95% CI -0.024-0.033, and p=0.738), and other patients’ characteristics.
Conclusions.
In patients with T2DM there is no correlation between S100B serum levels and newly detected mild depressive symptoms.
The brain biochemistry pathways of depression in T2DM warrant further investigation in a larger scale population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Katsanou, Panagiota& Tentolouris, Nicholas& Perrea, Despoina& Katsanos, Spyridon& Ntova, Vasiliki& Antrian, Virginia…[et al.]. 2018. S100B Levels in Patients with Type 2 Diabetes Mellitus and Co-Occurring Depressive Symptoms. Depression Research and Treatment،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153983
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Katsanou, Panagiota…[et al.]. S100B Levels in Patients with Type 2 Diabetes Mellitus and Co-Occurring Depressive Symptoms. Depression Research and Treatment No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1153983
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Katsanou, Panagiota& Tentolouris, Nicholas& Perrea, Despoina& Katsanos, Spyridon& Ntova, Vasiliki& Antrian, Virginia…[et al.]. S100B Levels in Patients with Type 2 Diabetes Mellitus and Co-Occurring Depressive Symptoms. Depression Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1153983
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153983
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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