Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer
المؤلفون المشاركون
Wan, Ting
Li, Luocheng
Zhu, Zhanyong
Liu, Siyang
Zhao, Yueqiang
Yu, Mosheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The epidermal growth factor (EGF) is recognized medicine of therapy in ulcer.
However, its efficacy has been challenged.
We compared scorpion venom active polypeptide and EGF of therapeutic effects in diabetic ulcer.
Methods.
The scorpion venom active polypeptide is made into gel.
Fourteen diabetic SD rats were randomly divided into scorpion peptide gel group (SPG group) and EGF group.
Before treatment, the rat model of diabetic ulcer was created.
The levels of IL-1, IL-6, IL-8, and TNF-α in the wound tissue were measured at different time points during the treatment, secretions of wound were collected for bacterial culture, and the wound healing was recorded.
Results.
Wound healing was faster in SPG group compared to EGF group (3 weeks versus 5 weeks, t-test, p=0.032).
The levels of IL-1, IL-6, IL-8, and TNF-α were not statistically different when the wounds were formed but showed significant differences from the 2nd to the 5th week between two groups.
The infection rate was higher in the EGF group (42.86% versus 0, Chi-square test, p=0.025).
Conclusions.
Scorpion venom active polypeptide shortens wound healing with a stronger anti-inflammation and antibacterial effect and may be a new and effective topical drug for the treatment of diabetic ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wan, Ting& Li, Luocheng& Zhu, Zhanyong& Liu, Siyang& Zhao, Yueqiang& Yu, Mosheng. 2017. Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wan, Ting…[et al.]. Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wan, Ting& Li, Luocheng& Zhu, Zhanyong& Liu, Siyang& Zhao, Yueqiang& Yu, Mosheng. Scorpion Venom Active Polypeptide May Be a New External Drug of Diabetic Ulcer. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر