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Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein
المؤلفون المشاركون
Undas, Anetta
Potaczek, Daniel P.
Jankowski, Miłosz
Szułdrzyński, Konstanty
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aims.
Fibrin formation and histidine-rich glycoprotein (HRG) are involved in primary hemostasis and wound healing.
Little is known regarding the relationship of clot characteristics, bleeding time, and wound healing.
Methods and Results.
We studied 154 patients with coronary artery disease (CAD) and 154 subjects free of CAD matched for age, obesity, and current smoking.
We evaluated bleeding time (BT) using standardized skin incisions on a forearm, along with plasma clot permeability (Ks), clot lysis time (CLT), and histidine-rich glycoprotein (HRG).
Compared with controls, BT was 45% shorter in CAD cases.
CAD patients had 32% lower Ks and 17% longer CLT as well as 50% lower HRG compared with controls (all p<0.001).
After adjusting for potential confounders, Ks and HRG levels were independent predictors of prolonged BT in CAD patients (OR 23.70, 95% CI 4.65-120.8 and OR 10.27, 95% CI 2.05-51.31, respectively) and controls (OR 10.89, 95% CI 2.31-51.11 and OR 4.54, 95% CI 1.07-19.27, respectively).
Scar formation (n=79, 25.6%) was independently predicted by both short and prolonged BT in CAD cases (OR 21.87, 95% CI 7.41-64.55 and OR 10.17, 95% CI 2.88-35.97) and controls (OR 5.94, 95% CI 2.29-15.41 and OR 14.76, 95% CI 4.29-50.77, respectively).
Conclusions.
The study shows that plasma fibrin clot density and HRG may influence BT and that appropriate skin wound healing is associated with medium BT.
Translational Perspective.
Elucidation of the complex relationships between plasma fibrin clot phenotype and wound healing might have important practical implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szułdrzyński, Konstanty& Jankowski, Miłosz& Potaczek, Daniel P.& Undas, Anetta. 2020. Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szułdrzyński, Konstanty…[et al.]. Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1153987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szułdrzyński, Konstanty& Jankowski, Miłosz& Potaczek, Daniel P.& Undas, Anetta. Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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