Predictive and Prognostic Role of PD-L1 in Urothelial Carcinoma Patients with Anti-PD-1PD-L1 Therapy: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Ye, Tao
Lu, Hongyan
Liu, Haoran
Yang, Xiaoqi
Lv, Peng
Wu, Xiaoliang
Ye, Zhangqun
Zhou, Hui
Tang, Kun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-27
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma (UC).
To evaluate the predictive and prognostic value of PD-L1 on response and survival in UC patients after cystectomy, chemotherapy, or anti-PD-1/PD-L1 therapy, a systematic review of PubMed, Embase, Web of Science, and the Cochrane Library was performed.
A total of 2154 patients from 14 published studies were included.
In all UC patients after cystectomy, tumour cell (TC) PD-L1 expression was not associated with the OS or PFS.
For the subset of patients with organ-confined disease, TC PD-L1 expression significantly predicted OS after cystectomy (P=0.0004).
There was no significant evidence of an association between TC PD-L1 status and ORR or OS for UC patients treated with platinum-based chemotherapy.
For UC patients treated with anti-PD-1/PD-L1 therapy, TC PD-L1 expression≥5% could predict the response (P=0.005), but not for the 1% cut-off (P≥0.05).
As for PD-L1 expression in tumour-inflating immune cells (TIICs), both subsets with IC2/3 vs.
IC0/1 and IC1/2/3 vs.
IC0 were associated with ORR to anti-PD-1/PD-L1 therapy.
In the TIIC subset, IC2/3 vs.
IC0/1 of PD-L1 was associated with higher CR (P=0.002), PR (P=0.04), and PD (P=0.007).
Further, higher TIIC PD-L1 status benefited from longer PFS (P<0.001), but was not associated with OS in UC patients with anti-PD-1/PD-L1 therapy.
Our study suggested that TIIC PD-L1 expression with 5% cut-off was valuable as a predictive and prognostic biomarker for ORR and PFS in UC patients with anti-PD-1/PD-L1 therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Haoran& Ye, Tao& Yang, Xiaoqi& Lv, Peng& Wu, Xiaoliang& Zhou, Hui…[et al.]. 2020. Predictive and Prognostic Role of PD-L1 in Urothelial Carcinoma Patients with Anti-PD-1PD-L1 Therapy: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1154031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Haoran…[et al.]. Predictive and Prognostic Role of PD-L1 in Urothelial Carcinoma Patients with Anti-PD-1PD-L1 Therapy: A Systematic Review and Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1154031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Haoran& Ye, Tao& Yang, Xiaoqi& Lv, Peng& Wu, Xiaoliang& Zhou, Hui…[et al.]. Predictive and Prognostic Role of PD-L1 in Urothelial Carcinoma Patients with Anti-PD-1PD-L1 Therapy: A Systematic Review and Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1154031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر