Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
المؤلفون المشاركون
Stjepanovic, Mihailo
Milovanovic, Tamara
Oluic, Branislav
Pavlovic Markovic, Aleksandra
Dragasevic, Sanja
Jovicic, Ivana
Stankovic, Sanja
Stojkovic, Mirjana
Stojkovic Lalosevic, Milica
Toncev, Ljubisa
Stojkovic, Stefan
Stulic, Milos
Culafic, Djordje
Stojanovic, Marija
Aleksic, Marko
Lalosevic, Jovan
Kiurski, Stanimir
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background and Aim.
Differentiating iron deficiency anemia (IDA) from anemia of chronic disease (ACD) in patients with inflammatory bowel disease (IBD) represents a clinical challenge.
Hepcidin is a polypeptide synthetized in the liver, and iron levels or inflammation mostly regulate hepcidin production.
Our aim was to determine serum hepcidin levels in patients with inflammatory bowel disease (IBD) as well to investigate whether hepcidin levels correlate with disease activity.
Material and Methods.
A case-control study was preformed among newly diagnosed IBD patients and same number age- and sex-matched healthy controls.
All patients underwent a total ileocolonoscopy.
Complete blood count was obtained in addition to inflammatory markers (CRP, erythrocyte sedimentation rate-ESR).
Serum levels of hepcidin were determined with commercially available enzyme-linked immunosorbent assay (DRG Instruments Marburg, Germany).
Serum iron, TIBC, and UIBC were assessed with an electrochemiluminesence immunoassay, and soluble transferrin receptor (sTfR) was assessed using an immunoturbidimetric method.
Mayo score and CDAI, respectively, were calculated for each patient.
Statistical analyses were performed using the SPSS software version 20.0 for Windows.
Results.
There was a high statistically significant difference between IBD patients and controls in levels of hepcidin (P<0.01).
Namely, serum hepcidin levels were significantly higher in the control group.
There was no statistically significant correlation of serum hepcidin with CRP, Mayo score, or CDAI, respectively (P>0.05).
However, we have found a statistically significant negative correlation of sTfR and TIBC with hepcidin (P<0.01).
Conclusion.
Results of our study suggest that hepcidin is a reliable marker of IDA in patients with IBD, and it could be used in routine clinical practice when determining adequate therapy in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stojkovic Lalosevic, Milica& Toncev, Ljubisa& Stankovic, Sanja& Dragasevic, Sanja& Stojkovic, Stefan& Jovicic, Ivana…[et al.]. 2020. Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease. Disease Markers،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stojkovic Lalosevic, Milica…[et al.]. Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease. Disease Markers No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1154039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stojkovic Lalosevic, Milica& Toncev, Ljubisa& Stankovic, Sanja& Dragasevic, Sanja& Stojkovic, Stefan& Jovicic, Ivana…[et al.]. Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر