Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors
المؤلفون المشاركون
Li, Weili
Liang, Tao
Zhang, Chunyang
Sun, Yongxing
Zhao, Ying
Shi, Shuhai
Cheng, Jingli
Zhang, Yunxin
Wang, Baoguo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Cerebral edema is a common complication of brain tumors in the perioperative period.
However, there is currently no reliable and convenient method to evaluate the extent of brain edema.
The objective is to explore the effectiveness of serum occludin on predicting the extent of perioperative brain edema and outcome in patients with brain tumors.
Methods.
This prospective study enrolled 55 patients with brain tumors and 24 healthy controls in Sanbo Brain Hospital from June 2019 through November 2019.
Serum occludin levels were measured preoperatively and on postoperative day 1.
Peritumoral edema was assessed preoperatively using MRI.
Pericavity brain edema on postoperative day 1 was evaluated using CT.
Results.
Compared with healthy controls, the serum occludin level was higher in patients with brain tumors both preoperatively and postoperatively (P<0.001).
The serum occludin level correlated positively with the degree of brain edema preoperatively (r=0.78, P<0.001) and postoperatively (r=0.59, P<0.001).
At an optimal cutoff of 3.015 ng/mL, the preoperative serum occludin level discriminated between mild and severe preoperative brain edema with a sensitivity of 90.48% and specificity of 84.62%.
At an optimal cutoff value of 3.033 ng/mL, the postoperative serum occludin level distinguished between mild and severe postoperative brain edema with a sensitivity of 97.30% and specificity of 55.56%.
Conclusions.
The serum occludin level is associated with cerebral edema and could potentially be used as a biomarker for perioperative cerebral edema.
This trial is registered with ChiCTR1900023742.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Shuhai& Cheng, Jingli& Zhang, Chunyang& Liang, Tao& Zhang, Yunxin& Sun, Yongxing…[et al.]. 2020. Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Shuhai…[et al.]. Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Shuhai& Cheng, Jingli& Zhang, Chunyang& Liang, Tao& Zhang, Yunxin& Sun, Yongxing…[et al.]. Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر