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The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Zhang, Li
Cheng, Yan-Li
Xue, Shuai
Xu, Zhong-Gao
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Diabetic nephropathy is a common and serious complication of diabetes mellitus (DM) and is one of the leading causes of end-stage renal disease worldwide.
Although there have been many investigations on biomarkers for DN, there is no consistent conclusion about reliable biomarkers.
The purpose of this study was to perform a systematic review and meta-analysis of the role of circulating retinol-binding protein 4 (RBP4) in the type 2 diabetes mellitus (T2DM) patients with kidney diseases.
Materials and Methods.
We searched the PubMed, MEDLINE, EMBASE, and Web of Science databases for publications.
For the 12 cross-sectional studies that we included in the review, we calculated standard mean differences (SMD) with 95% confidence intervals (CI) for continuous data when the applied scales were different.
Risk of bias of included trials was assessed by using the Newcastle-Ottawa Scale.
Results.
RBP4 concentrations in the micro-, macro-, or micro+macroalbuminuria groups were significantly higher than those in the normal albuminuria group of T2DM patients [P=0.001, SMD 1.07, 95% CI (0.41, 1.73)].
The estimated glomerular filtration rate (eGFR) was negatively associated with circulating RBP4 concentrations in patients with T2DM [summary Fisher’s Z=−0.48, 95% CI (-0.69, -0.26), P<0.0001].
The albumin-to-creatinine ratio (ACR) was positively associated with circulating RBP4 concentrations in patients with T2DM [summary Fisher’s Z=0.20, 95% CI (0.08, 0.32), P=0.001].
Conclusion.
The levels of circulating RBP4 were significantly higher both in T2DM subjects with micro/macroalbuminuria and in T2DM subjects with declined eGFR.
The levels of circulating RBP4 were positively correlated with ACR but negatively correlated with eGFR.
Circulating RBP4 could be a reliable biomarker for kidney diseases in T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Li& Cheng, Yan-Li& Xue, Shuai& Xu, Zhong-Gao. 2020. The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Li…[et al.]. The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1154081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Li& Cheng, Yan-Li& Xue, Shuai& Xu, Zhong-Gao. The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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