The Value of Haematological Parameters and Tumour Markers in the Prediction of Intestinal Obstruction in 1474 Chinese Colorectal Cancer Patients
المؤلفون المشاركون
Wu, Ke
Cao, Yinghao
Ke, Songqing
Gu, Junnan
Mao, Fuwei
Yao, Shuang
Deng, Shenghe
Cai, Kailin
Liu, Li
Yan, Lizhao
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Intestinal obstruction, a life-threatening problem, often occurs in patients with advanced colorectal cancer (CRC).
However, the cause of obstruction is still unknown.
Very few prediction models for intestinal obstruction in CRC exist, and their results are unreliable.
Therefore, we investigated whether preoperative serum tumour markers (STMs) combined with haematological and biochemical markers could be used as predictors.
We retrospectively analysed 1474 patients with CRC who underwent radical resection after admission.
Several clinical features, STMs, and serum biochemical and haematological indicators were analysed.
Predictors of intestinal obstruction were analysed with univariate and multivariate logistic regression.
The accuracy of the multivariate predictors of obstruction was measured by the area under the receiver operating characteristic (ROC) curve (AUC).
The Kaplan-Meier method was used to create survival curves.
Obstruction was found more in males (62.18%), never-smokers (73.95%), the left colon (54.20%), the tumour diameter>4.5 cm (55.88%), high differentiation (89.50%), and negative nerve invasion (70.17%).
The serum tumour markers (STMs) and peripheral blood routine indexes (PBRI) were significantly associated with obstructive status (p<0.05).
Multivariate analysis demonstrated that the neutrophil and lymphocyte counts, carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 125, albumin, alkaline phosphatase, gamma-glutamyl transpeptidase, total protein, and neutrophil-to-lymphocyte ratio were predictors of intestinal obstruction (p<0.05).
The AUC for the curve with all the eight factors was 0.715 (95% confidence interval: 0.673-0.758).
The STMs and PBRI were related to the obstruction status of the patients, and they could be used in combination with other clinical factors to significantly improve diagnosis and management of intestinal obstruction in CRC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Yinghao& Ke, Songqing& Gu, Junnan& Mao, Fuwei& Yao, Shuang& Deng, Shenghe…[et al.]. 2020. The Value of Haematological Parameters and Tumour Markers in the Prediction of Intestinal Obstruction in 1474 Chinese Colorectal Cancer Patients. Disease Markers،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Yinghao…[et al.]. The Value of Haematological Parameters and Tumour Markers in the Prediction of Intestinal Obstruction in 1474 Chinese Colorectal Cancer Patients. Disease Markers No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1154142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Yinghao& Ke, Songqing& Gu, Junnan& Mao, Fuwei& Yao, Shuang& Deng, Shenghe…[et al.]. The Value of Haematological Parameters and Tumour Markers in the Prediction of Intestinal Obstruction in 1474 Chinese Colorectal Cancer Patients. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر