Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers
المؤلفون المشاركون
Liu, Chuan
Zhang, Pu
Li, Mingyue
Huang, Yan
Lu, Yali
Wang, Dan
Wan, Xuechao
Wang, Chenji
Xu, Yangguang
Kong, Zhe
Ji, Chaoneng
Li, Liang
Li, Jing
Wang, Xinmei
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-06
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer.
However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear.
In the present study, we identified 469 novel androgen-responsive lncRNAs using microarray data.
After validating the accuracy of the array data, we constructed a transcriptional network which contained more than 30 transcriptional factors using ChIP-seq data to explore upstream regulators of androgen-responsive lncRNAs.
Next, we conducted bioinformatics analysis to identify lncRNA-miRNA-mRNA regulatory network.
To explore the potential roles of androgen-responsive lncRNAs in hormone-related cancers, we performed coexpression network and PPI network analyses using TCGA data.
GO and KEGG analyses showed these lncRNAs were mainly involved in regulating signal transduction, transcription, development, cell adhesion, immune response, cell differentiation, and MAPK signaling pathway.
We also highlight the prognostic value of HPN-AS1, TPTEP1, and LINC00623 in cancer outcomes.
Our results suggest that androgen-responsive lncRNAs played important roles in regulating hormone-related cancer progression and could be novel molecular biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Dan& Li, Mingyue& Li, Jing& Wan, Xuechao& Huang, Yan& Wang, Chenji…[et al.]. 2020. Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers. Disease Markers،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1154179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Dan…[et al.]. Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers. Disease Markers No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1154179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Dan& Li, Mingyue& Li, Jing& Wan, Xuechao& Huang, Yan& Wang, Chenji…[et al.]. Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1154179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر