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Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients
المؤلفون المشاركون
Leszek, Przemysław
Sochanowicz, Barbara
Brzóska, Kamil
Kraj, Leszek
Kuśmierczyk, Mariusz
Śmigielski, Witold
Rywik, Tomasz M.
Sobieszczańska-Małek, Małgorzata
Rozentryt, Piotr
Kruszewski, Marcin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Heart failure patients presenting with iron deficiency can benefit from systemic iron supplementation; however, there is the potential for iron overload to occur, which can seriously damage the heart.
Therefore, myocardial iron (M-Iron) content should be precisely balanced, especially in already failing hearts.
Unfortunately, the assessment of M-Iron via repeated heart biopsies or magnetic resonance imaging is unrealistic, and alternative serum markers must be found.
This study is aimed at assessing M-Iron in patients with advanced heart failure (HF) and its association with a range of serum markers of iron metabolism.
Methods.
Left ventricle (LV) myocardial biopsies and serum samples were collected from 33 consecutive HF patients (25 males) with LV dysfunction (LV ejection fraction 22 (11) %; NT-proBNP 5464 (3308) pg/ml) during heart transplantation.
Myocardial ferritin (M-FR) and soluble transferrin receptor (M-sTfR1) were assessed by ELISA, and M-Iron was determined by Instrumental Neutron Activation Analysis in LV biopsies.
Nonfailing hearts (n=11) were used as control/reference tissue.
Concentrations of serum iron-related proteins (FR and sTfR1) were assessed.
Results.
LV M-Iron load was reduced in all HF patients and negatively associated with M-FR (r=−0.37, p=0.05).
Of the serum markers, sTfR1/logFR correlated with (r=−0.42; p=0.04) and predicted (in a step-wise analysis, R2=0.18; p=0.04) LV M-Iron.
LV M-Iron load (μg/g) can be calculated using the following formula: 210.24–22.869×sTfR1/logFR.
Conclusions.
The sTfR1/logFR ratio can be used to predict LV M-Iron levels.
Therefore, serum FR and sTfR1 levels could be used to indirectly assess LV M-Iron, thereby increasing the safety of iron repletion therapy in HF patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leszek, Przemysław& Sochanowicz, Barbara& Brzóska, Kamil& Kraj, Leszek& Kuśmierczyk, Mariusz& Śmigielski, Witold…[et al.]. 2020. Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leszek, Przemysław…[et al.]. Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1154181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leszek, Przemysław& Sochanowicz, Barbara& Brzóska, Kamil& Kraj, Leszek& Kuśmierczyk, Mariusz& Śmigielski, Witold…[et al.]. Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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