Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate TransaminaseAlanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment
المؤلفون المشاركون
Kang, Minyong
Shin, Seung Jea
Sung, Hyun Hwan
Jeon, Hwang Gyun
Jeong, Byong Chang
Jeon, Seong Soo
Lee, Hyun Moo
Seo, Seong Il
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
This study is aimed at examining the prognostic role of pre-to-postoperative dynamics of De Ritis ratio (aspartate aminotransaminase (AST)/alanine aminotransaminase (ALT)) in patients with nonmetastatic renal cell carcinoma (RCC) following radical nephrectomy.
Methods.
We retrospectively reviewed the records of 670 patients who underwent radical nephrectomy for nonmetastatic RCC between 1996 and 2012 at our institution.
The cutoff points for preoperative (=1.0) and postoperative AST/ALT ratios (=1.12) were assigned based on the median values.
We categorized patients into four groups according to the dynamics of AST/ALT ratios: group 1 (lower (≤1.0) ⟶ lower (≤1.12)), group 2 (lower (≤1.0) ⟶ higher (>1.12)), group 3 (higher (>1.0) ⟶ lower (≤1.12)), and group 4 (higher (>1.0) → higher (>1.12)).
Results.
When grouped by a preoperative AST/ALT ratio alone, the groups were not statistically different in cancer-specific survival (CSS) or overall survival (OS).
In contrast, in Kaplan-Meier analysis, CSS (P=0.0296) and OS (P=0.0324) were both significantly shorter with an increased postoperative AST/ALT ratio.
According to the pre-to-postoperative dynamics of the AST/ALT ratio, group 2 (lower (≤1.0) ⟶ higher (>1.12)) had a significantly lower CSS (P=0.0028) and OS (P=0.0194) than the other groups.
On multivariate Cox regression analysis, the pre-to-postoperative dynamics of the AST/ALT ratio were a significant prognostic factor for CSS (hazard ratio, HR=3.45) and OS (HR=2.18).
Conclusion.
This study is the first to suggest that the dynamics of the pre-to-postoperative De Ritis ratio represent an independent prognostic factor for RCC patients following nephrectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Minyong& Shin, Seung Jea& Sung, Hyun Hwan& Jeon, Hwang Gyun& Jeong, Byong Chang& Jeon, Seong Soo…[et al.]. 2020. Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate TransaminaseAlanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Minyong…[et al.]. Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate TransaminaseAlanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Minyong& Shin, Seung Jea& Sung, Hyun Hwan& Jeon, Hwang Gyun& Jeong, Byong Chang& Jeon, Seong Soo…[et al.]. Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate TransaminaseAlanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر