The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients
المؤلفون المشاركون
Alzoubi, Karem H.
Al-qarqaz, Firas A.
Garba, Munir
Khabour, Omar F.
Abu-Siniyeh, Ahmed
المصدر
Dermatology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Acne is a common condition of pilosebaceous follicle especially among young.
Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin.
However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment.
Aim.
In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230).
Methods.
Several biochemical parameters were measured at baseline and after treatments with isotretinoin.
The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients.
Results.
Alterations in lipid profile with a significant increase of ALT (P=0.007) were detected after isotretinoin treatment.
Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (P=0.008).
On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected.
Conclusions.
Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Garba, Munir& Khabour, Omar F.& Alzoubi, Karem H.& Abu-Siniyeh, Ahmed& Al-qarqaz, Firas A.. 2020. The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients. Dermatology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154257
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Garba, Munir…[et al.]. The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients. Dermatology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1154257
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Garba, Munir& Khabour, Omar F.& Alzoubi, Karem H.& Abu-Siniyeh, Ahmed& Al-qarqaz, Firas A.. The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients. Dermatology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154257
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154257
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر