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The Immune Effects of an African Traditional Energy Tonic in In Vitro and In Vivo Models
المؤلفون المشاركون
Ngcobo, Mlungisi
Gqaleni, Nceba
Naidoo, Vinny
Cele, Protus
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Most of the African traditional medicines (ATM) are formulated as energy tonics to boost and maintain immune defences.
In this study, we aimed to evaluate the immune effects of a traditional energy tonic using peripheral blood mononuclear cells (PBMCs), THP-1 monocytes, and bacteria infected rats.
When tested in mitogen and peptidoglycan stimulated PBMCs, this energy tonic showed minimal cytotoxicity, while in acute toxicity studies in rats it did not exhibit any significant toxicity at doses up to 2000 mg/mL/kg.
The energy tonic doses between 100 and 10 μg/mL were shown to stimulate secretion of cytokines and increase sIL-2R levels in PHA-treated PBMCs.
Similar doses in PG-S.
aureus-stimulated PBMCs significantly (p<0.05) increased IL-1α, IL-2, and GM-CSF while causing a significant (p<0.05) decrease in sIL-2R levels.
NF-κβ transcriptional activity was increased in LPS stimulated THP-1 cells.
In Sprague Dawley rats pretreated with the energy tonic and then infected with S.
aureus, there were insignificant increases in cytokines and sIL-2R when compared to bacteria infected only and 5% Enrofloxacin treated rats.
Posttreatment with energy tonic doses after infection with S.
aureus did not enhance inflammatory cytokines significantly but changed the immune response profile and decreased corticosterone levels.
This ATM showed promising immunomodulatory effects on isolated immune cells and modulated the immune response of rat models infected with S.
aureus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ngcobo, Mlungisi& Gqaleni, Nceba& Naidoo, Vinny& Cele, Protus. 2017. The Immune Effects of an African Traditional Energy Tonic in In Vitro and In Vivo Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154264
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ngcobo, Mlungisi…[et al.]. The Immune Effects of an African Traditional Energy Tonic in In Vitro and In Vivo Models. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1154264
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ngcobo, Mlungisi& Gqaleni, Nceba& Naidoo, Vinny& Cele, Protus. The Immune Effects of an African Traditional Energy Tonic in In Vitro and In Vivo Models. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154264
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154264
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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