![](/images/graphics-bg.png)
The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkBNF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice
المؤلفون المشاركون
Lin, Dong
Zhang, Jie
Zhuang, Wanyu
Yan, Xiaodan
Yang, Xiaoting
Lin, Shen
Lin, Lili
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Our previous study showed that the acupuncture stimulation on the acupoint (ST-36) could activate the brain-derived neurotropic factor (BDNF) signaling pathways in telomerase-deficient mice.
Recently, we set out to investigate whether the manual acupuncture (MA) or electroacupuncture (EA) displays a therapeutic advantage on age-related deterioration of learning and memory.
Both telomerase-deficient mice (Terc−/− group, n=24) and wild-type mice (WT group, n=24) were randomly assigned to 3 subgroups (CON, controls with no treatment; MA, mice receiving manual acupuncture; EA, mice receiving electric acupuncture).
The mice were subjected to behavior test, and EA/MA were applied at bilateral acupoints (ST36) 30 min daily for 7 successive days.
The brain tissues were collected after the last Morris water maze (MWM) test and were subjected to the immunohistochemistry and western blot analysis.
The MWM test showed that EA can significantly increase the time in target quadrant (P≤0.01) and frequency of locating platform for Terc−/− mice (P≤0.05), while nothing changed in WT mice.
Furthermore, western blotting and immunohistochemistry suggested that EA could also specifically increase the expression of TrkB and NF-κB in Terc−/− mice but not in wild-type mice (P≤0.05).
Meanwhile, the expression level and ratio of ERK/p-ERK did not exhibit significant changes in each subgroup.
These results indicated that, compared with MA, the application of EA could specifically ameliorate the spatial learning and memory capability for telomerase-deficient mice through the activation of TrkB and NF-κB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Dong& Zhang, Jie& Zhuang, Wanyu& Yan, Xiaodan& Yang, Xiaoting& Lin, Shen…[et al.]. 2018. The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkBNF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Dong…[et al.]. The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkBNF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Dong& Zhang, Jie& Zhuang, Wanyu& Yan, Xiaodan& Yang, Xiaoting& Lin, Shen…[et al.]. The Effect of Electroacupuncture versus Manual Acupuncture through the Expression of TrkBNF-κB in the Subgranular Zone of the Dentate Gyrus of Telomerase-Deficient Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)