Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-α Stimulation
المؤلفون المشاركون
Kim, Hye Yoom
Kang, Dae Gill
Lee, Yun Jung
Ahn, You Mee
Choi, Eun Sik
Yoon, Jung Joo
Han, Byung Hyuk
Jeong, Da Hye
Eun, So Young
Lee, Ho Sub
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Samul-Tang (SMT), consisting of four medicinal herbs, is a well-known herbal prescription treating hematological disorders related symptoms.
Our previous study demonstrated that SMT attenuated inflammation of vascular endothelial cells.
In condition of retained vascular dysfunction, vascular inflammation is initiated and results in activation of smooth muscle cells (SMCs).
Activated SMCs lose control of cell cycle regulation and migrate into intima, resulting in formation of atheroma.
Here, we further investigated whether SMT suppresses proliferation and migration of SMCs.
SMT showed antiproliferative effects on SMCs by suppressing [3H]-thymidine incorporation against TNF-α stimulation.
Underlying mechanisms of antiproliferative effects were found to be resulting from cell cycle regulation.
SMT downregulated expression of cyclin D1-CDK4 and cyclin E-CDK2 complexes and upregulated p21waf1/cip1 and p27kip1.
SMT also suppressed migration of SMCs against TNF-α stimulation.
This is thought to have resulted from suppressing MMP2 and MMP9 expressions and ROS production.
In summary, SMT attenuates abnormal migration of vascular smooth muscle cells via regulating cell cycle and suppressing MMPs expression and ROS production.
Our study suggests that SMT, a traditionally used herbal formula, protects vascular smooth muscle cells and might be used as an antiatherosclerotic drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Eun Sik& Yoon, Jung Joo& Han, Byung Hyuk& Jeong, Da Hye& Kim, Hye Yoom& Ahn, You Mee…[et al.]. 2018. Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-α Stimulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Eun Sik…[et al.]. Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-α Stimulation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Eun Sik& Yoon, Jung Joo& Han, Byung Hyuk& Jeong, Da Hye& Kim, Hye Yoom& Ahn, You Mee…[et al.]. Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-α Stimulation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر