Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method
المؤلفون المشاركون
Zhu, Jixiao
Huang, Wei-Hua
Yuan, Chun-Su
Zeng, Jin-Xiang
Wang, Juan
Zhang, Shou-Wen
Li, Min
Wan, Jin-Yi
Yao, Hai-Qiang
Wang, Chong-Zhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The XOD inhibitory effects of Plantaginis Semen, that is, the seeds of P.
asiatisca, and its representative four single compounds, acteoside, 1H-indolo-3-carbaldehyde, isoacteoside, and myristic acid, were evaluated by electron transfer signal blocking activities (ETSBA), which is based on the electron transfer signal of XOD enzymatic reaction.
The blocking activities were detected using an electrochemical biosensing method.
Compared with control, significant effects were observed after the addition of P.
asiatica extract, acteoside, and 1H-indolo-3-carbaldehyde (all p<0.05).
The IC50 values of the extract and acteoside are 89.14 and 7.55 μg·mL−1, respectively.
The IC20 values of the extract, acteoside, and 1H-indolo-3-carbaldehyde are 24.28, 3.88, and 16.16 μg·mL−1, respectively.
Due to the relatively lower inhibitory potential of 1H-indolo-3-carbaldehyde, its IC50 was not obtained.
In addition, isoacteoside and myristic acid did not show any XOD inhibitory effects.
Our data demonstrated that the XOD inhibitory effects of the extract, acteoside, and 1H-indolo-3-carbaldehyde can be accurately evaluated by the ETSBA method.
The results from this study indicated that Plantaginis Semen significantly inhibited XOD activities to reduce hyperuricemia and treat gout.
The study also proves that measuring the electron transfer signal blocking activities is a simple, sensitive, and accurate method to evaluate the XOD inhibitory effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Jin-Xiang& Wang, Juan& Zhang, Shou-Wen& Zhu, Jixiao& Li, Min& Huang, Wei-Hua…[et al.]. 2018. Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Jin-Xiang…[et al.]. Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Jin-Xiang& Wang, Juan& Zhang, Shou-Wen& Zhu, Jixiao& Li, Min& Huang, Wei-Hua…[et al.]. Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر