Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1Smads Signaling Pathway
المؤلفون المشاركون
Chen, Hongshu
Xu, Yiqing
Yang, Yuanxiao
Zhou, Xiaojie
Dai, Shijie
Li, Changyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Epithelial-mesenchymal transition (EMT) refers to the transition of epithelial cells into mesenchymal cells.
Emerging evidence suggests that EMT is a key point in renal interstitial fibrosis (RIF).
Traditional Chinese Medicine Shenqiwan (SQW) is widely used in clinical treatment of chronic kidney disease, but the underlying mechanism remains unclear.
The purpose of this study is to investigate the effect of SQW on renal fibrosis and its association with TGF-β1/Smads signaling pathway.
A rat model of adenine (150 mg/kg) was established and intragastrically treated with various concentrations of SQW at dose of 1.5 g/kg, 3 g/kg, and 6 g/kg.
Control group and model group were given the same volume of saline.
Meanwhile, the positive control group was treated with Enalapril (4 mg/kg).
Animals were sacrificed on 21st day after administration.
The results showed that SQW could significantly relieve renal pathological damage caused by adenine, increase gene and protein expression of E-cadherin, and decrease the expression of Vimentin in kidney samples.
In addition, SQW efficiently inhibited the mRNA and protein expression of p-Smad2/3 by upregulating Smad7.
These results suggest that SQW could slow down the progression of renal fibrosis, possibly by inhibiting TGF-β1/Smads signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Hongshu& Xu, Yiqing& Yang, Yuanxiao& Zhou, Xiaojie& Dai, Shijie& Li, Changyu. 2017. Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1Smads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154469
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Hongshu…[et al.]. Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1Smads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154469
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Hongshu& Xu, Yiqing& Yang, Yuanxiao& Zhou, Xiaojie& Dai, Shijie& Li, Changyu. Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1Smads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154469
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154469
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر