Apoptosis of Platelets Inhibited By Herba Sarcandrae Extract through the Mitochondria Pathway
المؤلفون المشاركون
Zheng, Qin
Jiang, Yiling
Luo, Meihong
Zhu, Xiaoqin
Zhang, Aiping
Shi, Ling
Xia, Lemin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The purpose of the present study is to decode the underlying mechanism of Herba Sarcandrae that indicated antipurpuric effect and to unveil one of its primary components, flavonoids, which play an important role.
An immune mediated bone marrow failure (BMF) model in mouse was established by infusion thymus suspension cells after radiation in vivo.
Platelets isolated in vitro were prepared from normal mice and BMF mice, respectively.
The expressions of PS, P-selectin, PAC-1, Bax, Bad, Bid, and caspase-9 were examined by flow cytometry, and alteration of morphology of platelets under different conditions was observed.
Our results indicated that the number of platelets was increased by addition of total flavonoids, and some of apoptotic markers such as Bax, Bad, Bid, and Caspase-9 were downregulated.
In addition, the phosphatidylserine (PS) exposure on platelets was inhibited by total flavonoids, and the expressions of PAC-1 and P-selectin were decreased.
In conclusion, it is suggested that the total flavonoids of Herba Sarcandrae may inhibit the excessive platelet apoptosis through mitochondrial pathway.
In addition, activation of platelets may be also involved in mediating apoptosis of platelets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Xiaoqin& Jiang, Yiling& Zheng, Qin& Zhang, Aiping& Shi, Ling& Xia, Lemin…[et al.]. 2018. Apoptosis of Platelets Inhibited By Herba Sarcandrae Extract through the Mitochondria Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Xiaoqin…[et al.]. Apoptosis of Platelets Inhibited By Herba Sarcandrae Extract through the Mitochondria Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Xiaoqin& Jiang, Yiling& Zheng, Qin& Zhang, Aiping& Shi, Ling& Xia, Lemin…[et al.]. Apoptosis of Platelets Inhibited By Herba Sarcandrae Extract through the Mitochondria Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر