Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats
المؤلفون المشاركون
Deng, Bo
Jia, Li-qun
Tan, Huang-ying
Pan, Lin
Song, Aiping
Deng, Chao
Zhang, Pan
Liu, Sida
Zhang, Yanan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Irinotecan is a well-known chemotherapy drug for the treatment of various cancers.
However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug.
The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action.
We established a diarrhea rat model.
The condition of the rats was observed.
The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively.
The expression of Lgr5 and CD44 staining were used to observe intestinal stem cells (ISCs).
In addition, the activity of β-glucuronidase in the rats’ feces was measured.
Our results showed that the number of proliferating intestinal cells in the SXD groups was obviously higher, while the activity of caspase-3 was lower.
The expression of Lgr5 and the integrated option density (IOD) of CD44 stain were increased significantly by SXD.
Additionally, SXD decreased the activity of β-glucuronidase after irinotecan administration.
In conclusion, SXD exhibited preventive effects on irinotecan-induced diarrhea, and this action was associated with an inhibitory effect on intestinal apoptosis and β-glucuronidase and a promotive effect on intestinal cell proliferation due to increased maintenance of ISCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Chao& Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Zhang, Pan& Liu, Sida…[et al.]. 2017. Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Chao…[et al.]. Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Chao& Deng, Bo& Jia, Li-qun& Tan, Huang-ying& Zhang, Pan& Liu, Sida…[et al.]. Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر