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Kyungheechunggan-Tang-01, a New Herbal Medication, Suppresses LPS-Induced Inflammatory Responses through JAKSTAT Signaling Pathway in RAW 264.7 Macrophages
المؤلفون المشاركون
Jang, Eungyeong
Inn, Kyung-Soo
Lee, Jang-Hoon
Han, Hee-Soo
Shin, Ji-Sun
Park, Geonha
Jang, Young Pyo
Lee, Kyung-Tae
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Medicinal plants have been used as alternative therapeutic tools to alleviate inflammatory diseases.
The objective of this study was to evaluate anti-inflammatory properties of Kyungheechunggan-tang- (KCT-) 01, KCT-02, and Injinchunggan-tang (IJCGT) as newly developed decoctions containing 3–11 herbs in LPS-induced macrophages.
KCT-01 showed the most potent inhibitory effects on LPS-induced NO, PGE2, TNF-α, and IL-6 production among those three herbal formulas.
In addition, KCT-01 significantly inhibited LPS-induced iNOS and COX-2 at protein levels and expression of iNOS, COX-2, TNF-α, and IL-6 at mRNA levels.
Molecular data revealed that KCT-01 attenuated the activation of JAK/STAT signaling cascade without affecting NF-κB or AP-1 activation.
In ear inflammation induced by croton oil, KCT-01 significantly reduced edema, MPO activity, expression levels of iNOS and COX-2, and STAT3 phosphorylation in ear tissues.
Taken together, our findings suggest that KCT-01 can downregulate the expression of proinflammatory genes by inhibiting JAK/STAT signaling pathway under inflammatory conditions.
This study provides useful data for further exploration and application of KCT-01 as a potential anti-inflammatory medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Hee-Soo& Jang, Eungyeong& Shin, Ji-Sun& Inn, Kyung-Soo& Lee, Jang-Hoon& Park, Geonha…[et al.]. 2017. Kyungheechunggan-Tang-01, a New Herbal Medication, Suppresses LPS-Induced Inflammatory Responses through JAKSTAT Signaling Pathway in RAW 264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154534
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Hee-Soo…[et al.]. Kyungheechunggan-Tang-01, a New Herbal Medication, Suppresses LPS-Induced Inflammatory Responses through JAKSTAT Signaling Pathway in RAW 264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154534
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Hee-Soo& Jang, Eungyeong& Shin, Ji-Sun& Inn, Kyung-Soo& Lee, Jang-Hoon& Park, Geonha…[et al.]. Kyungheechunggan-Tang-01, a New Herbal Medication, Suppresses LPS-Induced Inflammatory Responses through JAKSTAT Signaling Pathway in RAW 264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154534
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154534
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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