Standardization of the Manufacturing Process of Bee Venom Pharmacopuncture Containing Melittin as the Active Ingredient
المؤلفون المشاركون
Lee, Yoonmi
Kim, Sung-Geun
Kim, In-Su
Lee, Hwa-Dong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Pharmacopuncture is a unique treatment in oriental medicine that combines chemical stimulation with conventional acupuncture.
However, there are no standardized methods for preparing the herbal medicines used in pharmacopuncture, and it is not clear whether the active ingredients are safe and stable.
Several studies have investigated nonstandardized preparation processes, but few investigations have addressed safety and preparation methods.
Pharmacopuncture may provide an alternative treatment for incurable diseases.
However, it must be as valid and safe as standardized medicine.
In this way, the present project may contribute to the industrialization of medicine in Korea.
It may also expand health insurance coverage by promoting evidence-based medical insurance benefits.
Thus, the present study attempted to standardize and improve the raw materials, preparation, and efficacy of bee venom pharmacopuncture (BVP), which is a highly effective technique in oriental medicine.
Method.
To purify the crude bee venom, the extract was subjected to a stepped-gradient open column (ODS-A; 120 Å, 150 mesh).
Using this method, the yield of melittin was significantly increased and the allergen proteins were effectively removed.
The melittin content of the purified bee venom was determined using HPLC, and the product was then diluted to 0.1 mg/mL using injection water in preparation for BVP.
Results.
In the present study, we standardized the purification process to provide safe and stable BVP by increasing the main effective components and eliminating allergens.
This study will be seminal in the industrialization and regulation of BVP.
Conclusion.
We developed an effective strategy for melittin purification and allergen removal from bee venom to create safe BVP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Yoonmi& Kim, Sung-Geun& Kim, In-Su& Lee, Hwa-Dong. 2018. Standardization of the Manufacturing Process of Bee Venom Pharmacopuncture Containing Melittin as the Active Ingredient. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Yoonmi…[et al.]. Standardization of the Manufacturing Process of Bee Venom Pharmacopuncture Containing Melittin as the Active Ingredient. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Yoonmi& Kim, Sung-Geun& Kim, In-Su& Lee, Hwa-Dong. Standardization of the Manufacturing Process of Bee Venom Pharmacopuncture Containing Melittin as the Active Ingredient. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر