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Identification of Tengfu Jiangya Tablet Target Biomarkers with Quantitative Proteomic Technique
المؤلفون المشاركون
Jiang, Haiqiang
Zhang, Shi-Jun
Xu, Jingwen
Wang, Nan
Lin, Haiqing
Li, Yunlun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tengfu Jiangya Tablet (TJT) is a well accepted antihypertension drug in China and its major active components were Uncaria total alkaloids and Semen Raphani soluble alkaloid.
To further explore treatment effects mechanism of TJT on essential hypertension, a serum proteomic study was performed.
Potential biomarkers were quantified in serum of hypertension individuals before and after taking TJT with isobaric tags for relative and absolute quantitation (iTRAQ) coupled two-dimensional liquid chromatography followed electrospray ionization-tandem mass spectrometry (2D LC-MS/MS) proteomics technique.
Among 391 identified proteins with high confidence, 70 proteins were differentially expressed (fold variation criteria, >1.2 or <0.83) between two groups (39 upregulated and 31 downregulated).
Combining with Gene Ontology annotation, KEGG pathway analysis, and literature retrieval, 5 proteins were chosen as key target biomarkers during TJT therapeutic process.
And the alteration profiles of these 5 proteins were verified by ELISA and Western Blot.
Proteins Kininogen 1 and Keratin 1 are members of Kallikrein system, while Myeloperoxidase, Serum Amyloid protein A, and Retinol binding protein 4 had been reported closely related to vascular endothelial injury.
Our study discovered 5 target biomarkers of the compound Chinese medicine TJT.
Secondly, this research initially revealed the antihypertension therapeutic mechanism of this drug from a brand-new aspect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Jingwen& Li, Yunlun& Zhang, Shi-Jun& Jiang, Haiqiang& Wang, Nan& Lin, Haiqing. 2017. Identification of Tengfu Jiangya Tablet Target Biomarkers with Quantitative Proteomic Technique. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154581
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Jingwen…[et al.]. Identification of Tengfu Jiangya Tablet Target Biomarkers with Quantitative Proteomic Technique. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154581
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Jingwen& Li, Yunlun& Zhang, Shi-Jun& Jiang, Haiqiang& Wang, Nan& Lin, Haiqing. Identification of Tengfu Jiangya Tablet Target Biomarkers with Quantitative Proteomic Technique. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154581
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154581
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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