Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress
المؤلفون المشاركون
Ye, Yi-Lu
Zhong, Kai
Liu, Dan-Dan
Xu, Jing
Pan, Bei-Bei
Yu, Yue-Ping
Zhang, Qi
Li, Xiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Neuroinflammation is considered as one of the common pathogeneses of depression.
Huanglian-Jie-Du-Tang (HJDT) is a traditional Chinese herbal formula.
The present study investigates the antidepressant-like effect of HJDT and its possible mechanism in rats.
Rats were given HJDT (2, 4, and 8 g/kg, intragastrically), paroxetine (1.8 mg/kg, intragastrically), or an equivalent volume of saline for 42 days.
The depression-related behaviors, including sucrose preference test (SPT), open field test (OFT), novel objective recognition task (NORT), and forced swimming test (FST), were detected.
5-Hydroxytryptamine (5-HT) and dopamine (DA) contents, microglial activation, proinflammatory cytokines, and brain derived neurotrophic factor (BDNF), tropomyosin receptor kinases B (TrkB), and cAMP-responsive element binding protein (CREB) expression were investigated.
The results indicated HJDT (2 and 4 g/kg) dramatically ameliorated the depression-like behaviors.
Also HJDT decreased the number of microglia and the proinflammatory cytokines in hippocampus.
Western-blotting analysis displayed HJDT upregulated BDNF, TrkB, and pCREB/CREB expression in hippocampus.
Particularly, pCREB DNA activity enhanced with HJDT treatment in hippocampus.
But there was no difference in the 5-HT and DA contents with HJDT treatment.
In conclusion, it was supposed that HJDT might be a potential Chinese medicine decoction for treating or alleviating complex symptoms of depression through BDNF-TrkB-CREB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Yi-Lu& Zhong, Kai& Liu, Dan-Dan& Xu, Jing& Pan, Bei-Bei& Li, Xiang…[et al.]. 2017. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Yi-Lu…[et al.]. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Yi-Lu& Zhong, Kai& Liu, Dan-Dan& Xu, Jing& Pan, Bei-Bei& Li, Xiang…[et al.]. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر