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Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1ROSNrf2 and TLR4NF-κB p65 Pathway
المؤلفون المشاركون
Li, Yu-Cui
Xu, Lieqiang
Liu, Yu-Hong
Chen, Jian-Nan
Xie, You-Liang
Huang, Qiong-Hui
Wu, Jia-Zhen
Wu, Xue
Lai, Xiao-Ping
Su, Zi-Ren
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Excessive alcohol consumption leads to serious liver injury, associating with oxidative stress and inflammatory response.
Previous study has demonstrated that polydatin (PD) exerted antioxidant and anti-inflammatory effects and attenuated ethanol-induced liver damage, but the research remained insufficient.
Hence, this experiment aimed to evaluate the hepatoprotective effect and potential mechanisms of PD on ethanol-induced hepatotoxicity.
Our results showed that PD pretreatment dramatically decreased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the serum, suppressed the malonaldehyde (MDA) and triglyceride (TG) content and the production of reactive oxygen species (ROS), and enhanced the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), andalcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH), paralleled by an improvement of histopathology alterations.
The protective effect of PD against oxidative stress was probably associated with downregulation of cytochrome P450 2E1 (CYP2E1) and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its target gene haem oxygenase-1 (HO-1).
Moreover, PD inhibited the release of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) via downregulating toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65.
To conclude, PD pretreatment protects against ethanol-induced liver injury via suppressing oxidative stress and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Qiong-Hui& Xu, Lieqiang& Liu, Yu-Hong& Wu, Jia-Zhen& Wu, Xue& Lai, Xiao-Ping…[et al.]. 2017. Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1ROSNrf2 and TLR4NF-κB p65 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Qiong-Hui…[et al.]. Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1ROSNrf2 and TLR4NF-κB p65 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1154633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Qiong-Hui& Xu, Lieqiang& Liu, Yu-Hong& Wu, Jia-Zhen& Wu, Xue& Lai, Xiao-Ping…[et al.]. Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1ROSNrf2 and TLR4NF-κB p65 Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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