![](/images/graphics-bg.png)
Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation
المؤلفون المشاركون
Guo, Zhuang-Li
Zhang, Baojian
Yu, Yanbing
Aori, Gele
Wang, Qi
Kong, Dawei
Yang, Wenqiang
Zhang, Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Diabetic peripheral neuropathic pain (DPNP) is a common and intractable complication of diabetes.
Conventional therapies are always not ideal; development of novel drugs is still needed to achieve better pain relief.
Recent evidences have demonstrated that inflammation is involved in the onset and maintenance of DPNP.
The anti-inflammatory property of Tanshinone IIA (TIIA) makes it a promising candidate to block or alter the pain perception.
This study was conducted to investigate whether TIIA could attenuate DPNP in streptozotocin- (STZ-) induced rats model and its potential mechanisms.
TIIA was administered to STZ-induced diabetic rats at the dose of 40 mg/kg once a day for 3 weeks.
The effects of TIIA on thermal hyperalgesia and mechanical allodynia were investigated using behavioral tests.
The mRNA level and expression of interleukin- (IL-) 1β, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 10 in the fourth to sixth segments of the dorsal root ganglion (L4–6 DRG) were detected by quantitative real-time PCR (qPCR) and Western blot.
TIIA treatment significantly attenuated mechanical allodynia and thermal hyperalgesia in diabetic rats.
In addition, the expression of the proinflammatory cytokines IL-1β, IL-6, and TNF-α was inhibited, and the level of the anti-inflammatory cytokine IL-10 was increased by TIIA.
This study demonstrated that TIIA has significant antiallodynic and antihyperalgesic effects in a rat model of STZ-induced DPNP, and the effect may be associated with its anti-inflammation property.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Baojian& Yu, Yanbing& Aori, Gele& Wang, Qi& Kong, Dawei& Yang, Wenqiang…[et al.]. 2018. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Baojian…[et al.]. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Baojian& Yu, Yanbing& Aori, Gele& Wang, Qi& Kong, Dawei& Yang, Wenqiang…[et al.]. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)