Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation
المؤلفون المشاركون
Guo, Zhuang-Li
Zhang, Baojian
Yu, Yanbing
Aori, Gele
Wang, Qi
Kong, Dawei
Yang, Wenqiang
Zhang, Li
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Diabetic peripheral neuropathic pain (DPNP) is a common and intractable complication of diabetes.
Conventional therapies are always not ideal; development of novel drugs is still needed to achieve better pain relief.
Recent evidences have demonstrated that inflammation is involved in the onset and maintenance of DPNP.
The anti-inflammatory property of Tanshinone IIA (TIIA) makes it a promising candidate to block or alter the pain perception.
This study was conducted to investigate whether TIIA could attenuate DPNP in streptozotocin- (STZ-) induced rats model and its potential mechanisms.
TIIA was administered to STZ-induced diabetic rats at the dose of 40 mg/kg once a day for 3 weeks.
The effects of TIIA on thermal hyperalgesia and mechanical allodynia were investigated using behavioral tests.
The mRNA level and expression of interleukin- (IL-) 1β, interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 10 in the fourth to sixth segments of the dorsal root ganglion (L4–6 DRG) were detected by quantitative real-time PCR (qPCR) and Western blot.
TIIA treatment significantly attenuated mechanical allodynia and thermal hyperalgesia in diabetic rats.
In addition, the expression of the proinflammatory cytokines IL-1β, IL-6, and TNF-α was inhibited, and the level of the anti-inflammatory cytokine IL-10 was increased by TIIA.
This study demonstrated that TIIA has significant antiallodynic and antihyperalgesic effects in a rat model of STZ-induced DPNP, and the effect may be associated with its anti-inflammation property.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Baojian& Yu, Yanbing& Aori, Gele& Wang, Qi& Kong, Dawei& Yang, Wenqiang…[et al.]. 2018. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Baojian…[et al.]. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Baojian& Yu, Yanbing& Aori, Gele& Wang, Qi& Kong, Dawei& Yang, Wenqiang…[et al.]. Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر