Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROSAkt Pathway in Glioma Cells
المؤلفون المشاركون
Jia, Feng
Ruan, Shu
Liu, Ning
Fu, Linshan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In our preliminary study, Berbamine (BA), one of the most commonly used traditional Chinese medicines, was effective in inducing the intracellular ROS levels.
Since the regulation of cellular antioxidant capacity is crucial to the sensitivity of Ptx, it is feasible to propose that sensitizing cells to Ptx can be achieved through increasing the antioxidant capacity by codelivering BA.
Cytotoxicity test demonstrates that either single or combinational treatment of BA and Ptx dose-dependently inhibits the proliferation of U-87 cells.
Median-effect analysis clearly proves the synergistic anticancer effect between BA and Ptx.
Combinational treatment of both drugs induced more intracellular ROS generation than either of the drugs did.
Cotreatment of NAC could partially reverse the ROS generation and ameliorate the cytotoxicity induced by BA plus Ptx.
Moreover, sequential activation of ROS-dependent phosphor-Akt expression was dose-dependently inhibited by the combinational application of BA and Ptx, which was more significantly effective than the single treatment of either BA or Ptx.
Additionally, the coadministration of BA and Ptx shows the strongest tumor delaying effect in a U87 xenograft model, demonstrating the synergism between two drugs.
Therefore, BA is a promising adjuvant to traditional chemotherapy, especially in combination with Ptx, to treat malignant glioma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Feng& Ruan, Shu& Liu, Ning& Fu, Linshan. 2017. Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROSAkt Pathway in Glioma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154675
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Feng…[et al.]. Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROSAkt Pathway in Glioma Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154675
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Feng& Ruan, Shu& Liu, Ning& Fu, Linshan. Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROSAkt Pathway in Glioma Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154675
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154675
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر